Transcription Factor
| Accessions: | DLX3_DBD (HumanTF 1.0), DLX3_TF2 (HumanTF2 1.0), DLX3 (HT-SELEX2 May2017) |
| Names: | DLX3, DLX3_HUMAN, ENSG00000064195 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2, HT-SELEX2 May2017 3 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 3 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | O60479 |
| Notes: | Ensembl ID: ENSG00000064195; DNA-binding domain sequence; TF family: homeodomain; Clone source: Gene synthesis, Ensembl ID: ENSG00000064195; Construct type: TF2(3xFLAG); TF family: Homeodomain; Clone source: Jolma et al. 2013, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 109 |
| Pfam Domains: | 26-82 Homeobox domain |
| Sequence: (in bold interface residues) | 1 AQDPVSVKEEPEAEVRMVNGKPKKVRKPRTIYSSYQLAALQRRFQKAQYLALPERAELAA 60 61 QLGLTQTQVKIWFQNRRSKFKKLYKNGEVPLEHSPNNSDSMACNSPPSP |
| Interface Residues: | 26, 27, 28, 29, 67, 68, 70, 71, 74, 75, 78, 79, 82 |
| 3D-footprint Homologues: | 3d1n_M, 5zfz_A, 1fjl_B, 5zjt_E, 2h1k_B, 1puf_A, 1ig7_A, 6a8r_A, 3cmy_A, 1mnm_C, 1nk2_P, 1zq3_P, 6m3d_C, 3lnq_A, 2lkx_A, 2ld5_A, 7q3o_C, 6es3_K, 4xrs_G, 2hos_A, 4cyc_A, 1au7_A, 5flv_I, 3a01_E, 7psx_B, 1b72_A, 5hod_A, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 1jgg_B, 7xrc_C, 1e3o_C, 2xsd_C, 1le8_A, 1k61_B, 3l1p_A, 1o4x_A, 8g87_X, 4qtr_D, 4xrm_B, 1du0_A, 1puf_B |
| Binding Motifs: | DLX3_DBD syAATTAm ERF_DLX3_1 avmGGAwryrgsyamTtr ERF_DLX3_2 rccGGAwrkvsyaaTta ETV2_DLX3_1 rcCGGAAryrrsskTAATtr ETV2_DLX3_2 acCGGAAryrvsvyaATtr ETV2_DLX3_2_3 rcCGGAAryrrgyaATTa ETV2_DLX3_2_3_4 TAATkrswacCGGAWryr GCM2_DLX3_1 aTrcGGGywkwyttAATtr GCM2_DLX3_2 aTrcGGGywrkdtAAttr MEIS1_DLX3 TGACAgsyTAATtr MGA_DLX3_1 AGGTGwTAATtr MGA_DLX3_2 yvATTAarGGTGtGAr TEAD4_DLX3_1 rCATwCCrhsyaATTA TEAD4_DLX3_2 rCATwCytyssTAATtr TEAD4_DLX3_2_3 rCATwCCdysstAAtkr TEAD4_DLX3_2_3_4 rCATwCCrmsyaATTA TFAP2C_DLX3_1 yssCysvrGGCaygggssTAATkr TFAP2C_DLX3_2 gsCCysrRGscaygskrTAATkr TFAP2C_DLX3_2_3 msCCybmrGsCaygcsymATTA TFAP4_DLX3_1 kCAGsTGdvggrsgyaATkr TFAP4_DLX3_2 yCAGsTGkdbgkrsgtaATtr TFAP4_DLX3_2_3 AwCAGCTGATywTAATtr TFAP4_DLX3_2_3_4 AwCAGCTGwTysssgYaatkr DLX3_3 syAATTAc DLX3_6 gyAATTAy DLX3_methyl_1 syAATTAb DLX3_methyl_2 vtcrTwAw DLX3_methyl_4 syAATTAb DLX3_methyl_5 vtCrTtAw |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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