Transcription Factor
| Accessions: | UP00305A (UniPROBE 20160601) |
| Names: | Ecm22, Extracellular matrix protein 22, Sterol regulatory element-binding protein ECM22, YLR228C |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q05958 |
| Description: | Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription |
| Length: | 130 |
| Pfam Domains: | 41-79 Fungal Zn(2)-Cys(6) binuclear cluster domain |
| Sequence: (in bold interface residues) | 1 TSDDGNAGQEREKDAELIEVGGKKVSKTSTGKRKFHNKSKTGCDNCKRRRVKCDEGKPFC 60 61 KKCTNMKLDCVYSPIQPRRRKDSSSSKFASAVHDRVGKKNLSDNAIMLQQQQQQLHHQQE 120 121 QQFRQQQQVQ |
| Interface Residues: | 47, 49, 50, 51, 52, 65, 66, 80, 82, 83 |
| 3D-footprint Homologues: | 1f5e_P, 1hwt_C, 1pyi_A, 6o19_A, 1zme_D, 7uik_T, 3coq_A, 6gys_C, 1d66_B |
| Binding Motifs: | UP00305A_1 wyyCGGGyskmCGGAvmw |
| Binding Sites: | AACCCTAA AACTCCGG ACTCCGGA AGTCCGGA ATCCGGAT ATTCCGGA ATTTCCGG CCGGAACA CCTCCGGA CTCCGGAA CTCCGGAC CTCCGGAG CTTCCGGA GCTCCGGA GTTCCGGA TCCCGGAA TCCGGAAA TCCGGAGA TTCCGGAA GTCCGGAA |
| Publications: | *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed] |
| Related annotations: | PaperBLAST |
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