Transcription Factor

						

			
Accessions: PO2F1_MOUSE (HOCOMOCO 10), P25425 (JASPAR 2024)

			
Names: NF-A1, Oct-1, Octamer-binding protein 1, Octamer-binding transcription factor 1, OTF-1, PO2F1_MOUSE, POU domain, class 2, transcription factor 1
Organisms: Mus musculus
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P25425
Length: 770
Pfam Domains:   282-355 Pou domain - N-terminal to homeobox domain
  383-439 Homeobox domain
Sequence: 
(in bold interface residues)		   1 MNNPSETNKSSMESEDASTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAGTS   60
  61 LQAAAQSLNVQSKSSEESGDSQQSSQPSSQPPSVQSAIPQTQLMLAGGQITGLTLTPAQQ  120
 121 QLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQL  180
 181 QQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQP  240
 241 QPSITLTSQPTTPTRTIAAASVQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRR  300
 301 IKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSD  360
 361 STASSPSALNSPGLGAEGLNRRRKKRTSIETNIRVALEKSFMENQKPTSEDITLIAEQLN  420
 421 MEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPASLVATTPSLVTSSTATTLT  480
 481 VNPVLPLTSAAVTNLSLTDQDLRRGCSWEVLRSLPDRVTTTAGTTDSTSNNNTATVISTA  540
 541 PPASSAVTSPSLSPSPSASASTSEASSASETNTTQTTSTPLPSPLGASQVMVTTPGLQTA  600
 601 AAALQGAAQLPANASLAAMAAAAGLSPGLMAPSQFAAGGALLSLSPGTLGSALSPALMSN  660
 661 STLATIQALASSGSLPITSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLV  720
 721 SAAAASTGNSAPTASLHASSTSTESIQSSLFTVASASGPASTTTAASKAQ
Interface Residues: 307, 323, 324, 325, 326, 328, 329, 335, 339, 382, 383, 384, 385, 386, 424, 425, 427, 428, 431, 432, 435, 436, 439
3D-footprint Homologues: 3d1n_M, 3l1p_A, 7u0g_M, 7xrc_C, 1au7_A, 8g87_X, 2xsd_C, 1o4x_A, 1e3o_C, 4j19_B, 3a01_E, 5jlw_D, 1puf_A, 5zjt_E, 4cyc_A, 1ig7_A, 2h1k_B, 3cmy_A, 1zq3_P, 1nk2_P, 1jgg_B, 3lnq_A, 2lkx_A, 6m3d_C, 7q3o_C, 2ld5_A, 6es3_K, 3rkq_B, 2r5y_A, 7psx_B, 2hos_A, 1b72_A, 2hdd_A, 1le8_A, 1k61_B, 1fjl_B, 4xrs_G, 5flv_I, 1du0_A, 5hod_A, 4qtr_D
Binding Motifs: PO2F1_MOUSE.H10MO.B|M01293 wATGcAAAt
PH0143.1 dtdwrwTAATTArktw
			
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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