Transcription Factor
| Accessions: | E2F7_DBD (HumanTF 1.0), E2F7 (HT-SELEX2 May2017) |
| Names: | E2F-7, E2F7, E2F7_HUMAN, Transcription factor E2F7, ENSG00000165891 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q96AV8 |
| Notes: | Ensembl ID: ENSG00000165891; DNA-binding domain sequence; TF family: E2F; Clone source: Gene synthesis, TF family: E2F experiment: HT-SELEX Hamming distance: 2 cycle: 3, TF family: E2F experiment: Methyl-HT-SELEX Hamming distance: 2 cycle: 3 |
| Length: | 255 |
| Pfam Domains: | 16-85 E2F/DP family winged-helix DNA-binding domain 156-241 E2F/DP family winged-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 VGDSAVDEFEKQRPSRKQKSLGLLCQKFLARYPSYPLSTEKTTISLDEVAVSLGVERRRI 60 61 YDIVNVLESLHLVSRVAKNQYGWHGRHSLPKTLRNLQRLGEEQKYEEQMAYLQQKELDLI 120 121 DYKFGERKKDGDPDSQEQQLLDFSEPDCPSSSANSRKDKSLRIMSQKFVMLFLVSKTKIV 180 181 TLDVAAKILIEESQDAPDHSKFKTKVRRLYDIANVLTSLALIKKVHVTEERGRKPAFKWI 240 241 GPVDFSSSDEELVDV |
| Interface Residues: | 16, 56, 57, 58, 59, 61, 204, 207, 208, 210 |
| 3D-footprint Homologues: | 4yo2_A, 1cf7_A, 1cf7_B |
| Binding Motifs: | E2F7_DBD tTTTCCCGCCAAAw E2F7_2 wTTTCCCGCCAAAw E2F7_methyl_1 wTTTCCCGCCAAAw |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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