Transcription Factor
| Accessions: | Q8K4J2 (JASPAR 2024) |
| Names: | COE4_MOUSE, Early B-cell factor 4, EBF-4, O/E-4, OE-4, Olf-1/EBF-like 4, Transcription factor COE4 |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q8K4J2 |
| Length: | 599 |
| Pfam Domains: | 256-338 IPT/TIG domain |
| Sequence: (in bold interface residues) | 1 MFPAQDALPRGGLHLKEEPLLPSSLGSVRSWMQSAGILDSNTAAQSGVGLARAHFEKQPP 60 61 SNLRKSNFFHFVLAMYDRQGQPVEVERTAFIDFVEKDREPGTEKTNNGIHYRLRLVYNNG 120 121 LRTEQDLYVRLIDSMSKQAIIYEGQDKNPEMCRVLLTHEIMCSRCCDRKSCGNRNETPSD 180 181 PVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSK 240 241 HGRRARRLDPSEAATPCIKAISPGEGWTTGGATVIIIGDNFFDGLQVVFGNVLLWSELIT 300 301 PHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFVYTALNEPTIDYGFQRLQKVIPRH 360 361 PGDPERLPKEVLLKRAADLAEALYGVPSSNQELLLKRAADVAEALYSAPRAPAPLGPLAP 420 421 SHPHPAVVGINAFSSPLAIAVGDTTPEPGYARSCGSASPRFAPSPGSQQSSYGSGLGAGL 480 481 GSYGAPGVTGLGVPGSPSFLNGSTATSPFAIMPSSPPLAAASSMSLPAAAPTTSVFSFSP 540 541 VNMICAVKQRSAFAPVLRPPSSPSQACPRAHREGLPDQPFEDTDKFHSAARGLQGLAYS |
| Interface Residues: | 64, 66, 67, 164, 173, 203, 205, 237, 238, 239, 240 |
| 3D-footprint Homologues: | 3mln_A, 3mlp_F |
| Binding Motifs: | UN0672.1 rrTCCCCAGGGGAcy MA2122.1 TCCCCAGGGGA |
| Binding Sites: | UN0672.1.1 UN0672.1.10 UN0672.1.11 UN0672.1.12 UN0672.1.13 UN0672.1.14 UN0672.1.15 UN0672.1.16 UN0672.1.17 UN0672.1.18 UN0672.1.19 UN0672.1.2 UN0672.1.20 UN0672.1.3 UN0672.1.4 UN0672.1.5 UN0672.1.6 UN0672.1.7 UN0672.1.8 UN0672.1.9 MA2122.1.5 MA2122.1.7 MA2122.1.1 MA2122.1.10 MA2122.1.11 MA2122.1.12 / MA2122.1.20 MA2122.1.13 MA2122.1.14 MA2122.1.15 / MA2122.1.19 MA2122.1.16 MA2122.1.17 MA2122.1.18 MA2122.1.2 MA2122.1.3 MA2122.1.4 / MA2122.1.9 MA2122.1.6 MA2122.1.8 |
| Publications: | Kubo S, Kataria R, Yao Y, Gabrielski JQ, Zheng L, Markowitz TE, Chan W, Song J, Boddapati AK, Saeki K, Haupl B, Park AY, Cheng YH, Cui J, Oellerich T, Lenardo MJ. Early B cell factor 4 modulates FAS-mediated apoptosis and promotes cytotoxic function in human immune cells. Proc Natl Acad Sci U S A : (2022). [Pubmed] |
| Related annotations: | PaperBLAST |
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