Transcription Factor
| Accessions: | TBX3_TF2 (HumanTF2 1.0), TBX3 (HT-SELEX2 May2017) |
| Names: | T-box protein 3, T-box transcription factor TBX3, TBX3, TBX3_HUMAN, ENSG00000135111 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF2 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | O15119 |
| Notes: | Ensembl ID: ENSG00000135111; Construct type: TF2(3xFLAG); TF family: Tbox; Clone source: Megaman, TF family: T_box experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: T_box experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 242 |
| Pfam Domains: | 20-143 T-box 154-221 T-box |
| Sequence: (in bold interface residues) | 1 AHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRGTEMVITKSGRRMFPPFKVRCSGLD 60 61 KKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMSKVVTF 120 121 HKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPRFHIVRANDILKLP 180 181 YSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMRV 240 241 FD |
| Interface Residues: | 46, 198, 199, 215, 218, 219 |
| 3D-footprint Homologues: | 1h6f_B, 5flv_I, 1xbr_B, 6f59_B, 2x6v_A, 4a04_B |
| Binding Motifs: | CLOCK_TBX3 sGTGTgrdysgCACGTG CUX1_TBX3 rgGTGTgrrtGATCrAT HOXB13_TBX3_1 cycrTAAwTcaCACst HOXB13_TBX3_2 cymrTAAAmsTcaCACcy HOXB2_TBX3 rGGTGTTAATkr TBX3 agGTGTbr TBX3_2 ragGTGTsaa TBX3_methyl_1 rAGGTGTgAa |
| Publications: | Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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