Transcription Factor
| Accessions: | NKX2-3 (HT-SELEX2 May2017) |
| Names: | ENSG00000119919, NKX2-3 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Notes: | TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 114 |
| Pfam Domains: | 30-86 Homeobox domain |
| Sequence: (in bold interface residues) | 1 KSCQLKKSLETAGDCKAAEESERPKPRSRRKPRVLFSQAQVFELERRFKQQRYLSAPERE 60 61 HLASSLKLTSTQVKIWFQNRRYKCKRQRQDKSLELGAHAPPPPPRRVAVPVLVR |
| Interface Residues: | 1, 29, 30, 31, 32, 33, 71, 72, 74, 75, 78, 79, 82, 83, 86 |
| 3D-footprint Homologues: | 1au7_A, 5zfz_A, 4j19_B, 3a01_E, 6a8r_A, 3d1n_M, 1fjl_B, 1ig7_A, 2h1k_B, 1puf_A, 5zjt_E, 3cmy_A, 1nk2_P, 1zq3_P, 6m3d_C, 2lkx_A, 7q3o_C, 6es3_K, 2ld5_A, 5hod_A, 3rkq_B, 2r5y_A, 2hos_A, 1b72_A, 4xrs_G, 5flv_I, 3lnq_A, 1jgg_B, 2hdd_A, 7psx_B, 5jlw_D, 1e3o_C, 2xsd_C, 1le8_A, 7xrc_C, 1puf_B, 1k61_B, 4xrm_B, 4cyc_A, 3l1p_A, 1o4x_A, 1le8_B, 1du0_A, 8g87_X, 4qtr_D, 1mnm_C |
| Binding Motifs: | NKX2-3_3 msCACTTras NKX2-3_6 vsCACTTrac NKX2-3_methyl_1 msCACTTvac NKX2-3_methyl_2 rtCGTTrag NKX2-3_methyl_4 msCACTTvac NKX2-3_methyl_5 vdcGTTrws |
| Related annotations: | PaperBLAST |
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