Transcription Factor

						

			
Accessions: GATA3_full (HumanTF 1.0), GATA3_TF2 (HumanTF2 1.0)

			
Names: GATA-binding factor 3, GATA3, GATA3_HUMAN, Trans-acting T-cell-specific transcription factor GATA-3
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, HumanTF2 1.0 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Uniprot: P23771
Notes: Ensembl ID: ENSG00000107485; Full protein sequence; TF family: GATA; Clone source: hORFeome, Ensembl ID: ENSG00000107485; Construct type: TF2(3xFLAG); TF family: znfGATA; Clone source: Jolma et al. 2013
Length: 444
Pfam Domains:   263-296 GATA zinc finger
  317-349 GATA zinc finger
Sequence: 
(in bold interface residues)		   1 MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFNIDGQGNHV   60
  61 PPYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKT  120
 121 SIHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDE  180
 181 KECLKYQVPLPDSMKLESSHSRGSMTALGGASSSTHHPITTYPPYVPEYSSGLFPPSSLL  240
 241 GGSPTGFGCKSRPKARSSTGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPL  300
 301 IKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEG  360
 361 IQTRNRKMSSKSKKCKKVHDSLEDFPKNSSFNPAALSRHMSSLSHISPFSHSSHMLTTPT  420
 421 PMHPPSSLSFGPHHPSSMVTAMG*
Interface Residues: 107, 108, 272, 273, 275, 285, 289, 326, 327, 329, 339, 343, 344, 347, 364, 366, 367
3D-footprint Homologues: 2fr4_L, 3vd6_C, 4hc9_A, 1gat_A, 3dfx_B, 4gat_A
Binding Motifs: GATA3_full wGATAAsr
TEAD4_GATA3 wGATAAsrrwGGAATGy
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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