Transcription Factor
| Accessions: | LBX2_DBD (HumanTF 1.0), LBX2 (HT-SELEX2 May2017) |
| Names: | Ladybird homeobox protein homolog 2, LBX2, LBX2_HUMAN, Transcription factor LBX2, ENSG00000179528 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q6XYB7 |
| Notes: | Ensembl ID: ENSG00000179528; DNA-binding domain sequence; TF family: homeodomain; Clone source: Gene synthesis, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 2 cycle: 4, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 2 cycle: 4 |
| Length: | 158 |
| Pfam Domains: | 69-125 Homeobox domain |
| Sequence: (in bold interface residues) | 1 DILAPRMVPRAPSAPQLPESGPGPTSPLCALEELTSKTFRGLDARALQPSEGRAGPDALG 60 61 PGPFGRKRRKSRTAFTAQQVLELERRFVFQKYLAPSERDGLATRLGLANAQVVTWFQNRR 120 121 AKLKRDVEEMRADVASLRALSPEVLCSLALPEGAPDPG |
| Interface Residues: | 69, 70, 71, 72, 110, 111, 113, 114, 117, 118, 121, 122, 125 |
| 3D-footprint Homologues: | 1ig7_A, 3d1n_M, 2h1k_B, 1puf_A, 1fjl_B, 6a8r_A, 3cmy_A, 5zfz_A, 1zq3_P, 1jgg_B, 3lnq_A, 2lkx_A, 1nk2_P, 2ld5_A, 7q3o_C, 6es3_K, 2r5y_A, 6m3d_C, 5flv_I, 2hos_A, 5zjt_E, 4cyc_A, 7psx_B, 5hod_A, 3a01_E, 1b72_A, 5jlw_D, 1puf_B, 4xrs_G, 2hdd_A, 3rkq_B, 1e3o_C, 2xsd_C, 2h8r_B, 1le8_A, 1ic8_B, 7xrc_C, 1o4x_A, 8g87_X, 3l1p_A, 4qtr_D, 1du0_A |
| Binding Motifs: | LBX2_DBD_1 cTsrAystrATTA LBX2_DBD_2 rcyAATTArc LBX2_4 CymrTTAATTAg LBX2_5 CTyrTTAa LBX2_6 sCyAATTArc LBX2_methyl_1 cTmATTAATTAT LBX2_methyl_2 CTCrTTAa LBX2_methyl_3 vyyMATTArc |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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