Transcription Factor
| Accessions: | IKZF1_HUMAN (HOCOMOCO 10), Q13422 (JASPAR 2024) |
| Names: | DNA-binding protein Ikaros, Ikaros family zinc finger protein 1, IKZF1_HUMAN, Lymphoid transcription factor LyF-1 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 519 |
| Pfam Domains: | 132-155 Zinc-finger double domain 145-167 C2H2-type zinc finger 145-167 Zinc finger, C2H2 type 159-182 Zinc-finger double domain 173-195 C2H2-type zinc finger 173-195 Zinc finger, C2H2 type 188-211 Zinc-finger double domain 201-224 Zinc finger, C2H2 type 201-224 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVASNVKVE 60 61 TQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCD 120 121 ICGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNY 180 181 ACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPGTLYPVI 240 241 KEETNHSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLGDKGLSDTPYDSSASYE 300 301 KENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPR 360 361 SNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAP 420 421 HARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIH 480 481 MGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS |
| Interface Residues: | 117, 127, 128, 129, 130, 131, 133, 134, 135, 136, 137, 140, 142, 155, 156, 157, 158, 159, 160, 161, 162, 163, 166, 183, 184, 185, 186, 187, 188, 189, 190, 191, 194, 199, 212, 213, 214, 215, 216, 217, 218 |
| 3D-footprint Homologues: | 2kmk_A, 8cuc_F, 7y3l_A, 7n5w_A, 5k5i_A, 8ssq_A, 7w1m_H, 5und_A, 8ssu_A, 1ubd_C, 5v3j_F, 2i13_A, 8gn3_A, 1mey_C, 5kkq_D, 5yel_A, 5ei9_F, 4m9v_C, 7eyi_G, 8h9h_G, 6e94_A, 7y3m_I, 2jpa_A, 5kl3_A, 7ysf_A, 6wmi_A, 6ml4_A, 6blw_A, 1yuj_A, 3uk3_C, 6jnm_A, 2drp_D, 1g2f_F, 5yj3_D, 2gli_A, 4x9j_A, 2wbs_A, 1f2i_J, 6u9q_A, 7txc_E, 1tf6_A, 2lt7_A, 1tf3_A, 6a57_A, 1llm_D, 5k5l_F |
| Binding Motifs: | IKZF1_HUMAN.H10MO.C|M01264 yTGGGArr MA1508.1 rrAACAGGAAry MA1508.2 AACAGGAA |
| Binding Sites: | MA1508.2.17 / MA1508.2.20 / MA1508.2.5 MA1508.2.1 / MA1508.2.16 MA1508.1.1 MA1508.1.10 / MA1508.1.6 MA1508.1.11 / MA1508.1.12 / MA1508.1.7 / MA1508.1.8 MA1508.1.13 / MA1508.1.9 MA1508.1.14 MA1508.1.10 / MA1508.1.15 MA1508.1.16 MA1508.1.17 MA1508.1.18 MA1508.1.19 MA1508.1.2 MA1508.1.11 / MA1508.1.20 MA1508.1.3 MA1508.1.4 MA1508.1.2 / MA1508.1.5 MA1508.1.3 / MA1508.1.6 MA1508.1.4 / MA1508.1.7 MA1508.1.8 MA1508.1.5 / MA1508.1.9 MA1508.1.12 MA1508.1.13 MA1508.1.14 MA1508.1.15 MA1508.1.16 MA1508.1.17 MA1508.1.18 MA1508.1.19 MA1508.1.20 MA1508.2.10 / MA1508.2.11 / MA1508.2.9 MA1508.2.12 / MA1508.2.4 MA1508.2.13 MA1508.2.14 MA1508.2.15 / MA1508.2.18 / MA1508.2.2 MA1508.2.19 MA1508.2.3 / MA1508.2.7 / MA1508.2.8 MA1508.2.6 |
| Publications: | Hu Y, Zhang Z, Kashiwagi M, Yoshida T, Joshi I, Jena N, Somasundaram R, Emmanuel AO, Sigvardsson M, Fitamant J, El-Bardeesy N, Gounari F, Van Etten RA, Georgopoulos K. Superenhancer reprogramming drives a B-cell-epithelial transition and high-risk leukemia. Genes Dev 30:1971-90 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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