Transcription Factor
| Accessions: | UP00359A (UniPROBE 20160601) |
| Names: | CND-1, hlh-5 |
| Organisms: | Caenorhabditis elegans |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P46581 |
| Description: | C. elegans Neuro D homolog: cnd-1 encodes a basic helix-loop-helix protein that is most closely related to the vertebrate NeuroD transcription factors; during development, CND-1 is predicted to function as a transcriptional regulator whose activity is required for several aspects of motor neuron fate specification, including cell division patterns, proper spatiotemporal expression of fate-specific markers, and normal axonal morphology and pathfinding; CND-1::GFP expression begins in early embryogenesis (< |
| Length: | 191 |
| Pfam Domains: | 19-71 Helix-loop-helix DNA-binding domain 77-187 Neuronal helix-loop-helix transcription factor |
| Sequence: (in bold interface residues) | 1 RPTDTSNFAPAEISKRKVRRVKANGRERARMHGLNNALDMLREYIPITTQHQKLSKIETL 60 61 RLARNYIDALQRMLQTNEQPTPLEYAHTLANGLSQTTTNMLANLLQVQPRQLLPPSQFDI 120 121 FSDPSHHQLHPSHPPPHSSFSSSSPSSSCSPPQYYYSPTQPSAAPLQGSCDPQYQQMYHQ 180 181 HSHQNTFNYSP |
| Interface Residues: | 20, 23, 24, 26, 27, 30, 31 |
| 3D-footprint Homologues: | 2ypa_A, 7z5k_B, 5i50_B, 2ql2_D, 2ql2_A |
| Binding Motifs: | UP00359A_1 wkdraaaaraastm UP00359A_2 mskaACAkCTGTyyaa |
| Binding Sites: | AACAGATG AACAGCTG AACATATG ACAGCTGT TTAATTAA AACATCTG AATTTAGT ACAGATGG ACAGATGT ACATATGG ACATATGT ACATCTGG ACCAGATG ACCATATG CAGATGGC CATATGGA CATCTGTC CCAGATGG CCATATGG TGTTAACA |
| Publications: | Grove C.A, De Masi F, Barrasa M.I, Newburger D.E, Alkema M.J, Bulyk M.L, Walhout A.J. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell 138:314-27 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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