Transcription Factor
| Accessions: | 5kl5_A (3D-footprint 20231221) |
| Names: | Wilms tumor protein, WT1_HUMAN, WT33 |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P19544 |
| Length: | 88 |
| Pfam Domains: | 5-29 C2H2-type zinc finger 5-29 Zinc finger, C2H2 type 21-46 Zinc-finger double domain 35-57 C2H2-type zinc finger 35-57 Zinc finger, C2H2 type 35-55 Zinc-finger of C2H2 type 49-75 Zinc-finger double domain 63-85 C2H2-type zinc finger 63-87 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 SEKPYQCDFKDCERRFSRSDHLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGE 60 61 KPFSCRWPSCQKKFARSDELVRHHNMHQ |
| Interface Residues: | 17, 18, 19, 20, 21, 23, 24, 45, 46, 47, 48, 49, 50, 51, 52, 53, 71, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83 |
| 3D-footprint Homologues: | 6jnm_A, 8cuc_F, 1tf3_A, 7y3l_A, 6ml4_A, 7n5w_A, 5yel_A, 4x9j_A, 2i13_A, 5kl3_A, 2wbs_A, 1ubd_C, 7ysf_A, 5ei9_F, 2jpa_A, 8ssq_A, 1mey_C, 7w1m_H, 5und_A, 2drp_D, 1f2i_J, 7eyi_G, 5k5i_A, 2kmk_A, 8ssu_A, 2gli_A, 1g2f_F, 6blw_A, 5kkq_D, 2lt7_A, 1tf6_A, 6u9q_A, 8h9h_G, 5v3j_F, 6e94_A, 6wmi_A, 7y3m_I, 6a57_A, 8gn3_A, 3uk3_C, 1llm_D, 7txc_E, 5yj3_D, 4m9v_C |
| Binding Motifs: | 5kl5_A GCGTGGGgt |
| Binding Sites: | 5kl5_B 5kl5_C |
| Publications: | Hashimoto H, Zhang X, Zheng Y, Wilson GG, Cheng X. Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications. Nucleic Acids Res 44:10165-10176 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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