Transcription Factor

Accessions: UP00476A (UniPROBE 20160601)
Names: Ylr278c
Organisms: Saccharomyces cerevisiae
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Description: Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene
Length: 39
Pfam Domains: 1-31 Fungal Zn(2)-Cys(6) binuclear cluster domain
Sequence:
(in bold interface residues)
1 RSCLLCRRRKQRCDHKLPSCTACLKAGIKCVQPSKYSSS
Interface Residues: 9, 10, 11, 35
3D-footprint Homologues: 1hwt_C, 1pyi_A, 6o19_A, 2er8_C, 7uik_T, 3coq_A, 6gys_C, 1zme_D, 1d66_B
Binding Motifs: UP00476A_1 / UP00476A_2 ghskybaAACTCCGrvyckggs
UP00476A_3 CGGAgTCCG
Binding Sites: AAACTCCG
AACTCCGA
AACTCCGC
AACTCCGG
AACTCCGT
AAGTCCGA
AATCTCCG
ACTCCGAA
ACTCCGAT
ACTCCGGA
ATACTCCG
ATCCGGAG
ATCTCCGG
CAACTCCG
CCGGAGAA
CGGAGATA
CGGAGTTA
CGGAGTTC
TCCGGAGA
CCGGAGTA
Publications: Gordân R, Murphy KF, McCord RP, Zhu C, Vedenko A, Bulyk ML. Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. Genome Biol : (2011). [Pubmed]
Related annotations: PaperBLAST

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