Transcription Factor

						

			
Accessions: Mafb_DBD (HumanTF 1.0), UP00045A (UniPROBE 20160601)

			
Names: Kreisler, Maf-B, Mafb, MAFB_MOUSE, Segmentation protein Kr, Transcription factor Maf-1, Transcription factor MafB, V-maf musculoaponeurotic fibrosarcoma oncogene homolog B, kr, Krml, Krml1, Maf1, protein B (avian), Transcription factor MAF1, v-maf musculoaponeurotic fibrosarcoma oncogene family
Organisms: Mus musculus
Libraries: HumanTF 1.0 1, UniPROBE 20160601 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: P54841
Description: v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian): Mus musculus v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) (Mafb), mRNA
Notes: Ensembl ID: ENSMUSG00000074622; DNA-binding domain sequence; TF family: bZIP; Clone source: Hughes lab.
Length: 125
Pfam Domains:    16-109 bZIP Maf transcription factor
Sequence: 
(in bold interface residues)		   1 ATAAATAAGGNGSVEDRFSDDQLVSMSVRELNRHLRGFTKDEVIRLKQKRRTLKNRGYAQ   60
  61 SCRYKRVQQKHHLENEKTQLIQQVEQLKQEVSRLARERDAYKVKCEKLANSGFREAGSTS  120
 121 DSPSS
Interface Residues: 51, 55, 56, 58, 59, 60, 62, 63
3D-footprint Homologues: 4eot_A, 7x5e_F, 2wt7_B, 7x5e_E, 5vpe_D, 6d6v_A
Binding Motifs: UP00045A_1 aawwkTGCTGACwwarm
Mafb_DBD_1 awwwTGCTGACd
Mafb_DBD_2 wdTGCTGAsTCAGCatw
Mafb_DBD_3 wdyGCTGACGTmAGCAyw
UP00045A_2 maatTGCAaAAwwrt
Binding Sites: AAGTCAGC
AATCAGCA
AATGCTGA
ACGTCAGC
ACTCAGCA
AGTCAGCA
AGTGCTGA
ATCAGCAC
ATGCTGAC
ATTGCTGA
ATTTGCTG
CGTCAGCA
CTGCTGAC
GCTGACAC
GCTGACGA
GGTCAGCA
GTCAGCAA
GTCAGCAC
TCAGCAAA
TGCTGACA
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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