Transcription Factor
| Accessions: | 1efa_B (3D-footprint 20231221) |
| Names: | LAC REPRESSOR, LACI_ECOLI |
| Organisms: | Escherichia coli, strain K12 |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P03023 |
| Length: | 330 |
| Pfam Domains: | 4-49 Bacterial regulatory proteins, lacI family 77-325 Periplasmic binding proteins and sugar binding domain of LacI family 77-310 Periplasmic binding protein domain 170-328 Periplasmic binding protein-like domain |
| Sequence: (in bold interface residues) | 1 KPVTLYDVAEYAGVSYQTVSRVVNQASHVSAKTREKVEAAMAELNYIPNRVAQQLAGKQS 60 61 LLIGVATSSLALHAPSQIVAAIKSRADQLGASVVVSMVERSGVEACKTAVHNLLAQRVSG 120 121 LIINYPLDDQDAIAVEAACTNVPALFLDVSDQTPINSIIFSHEDGTRLGVEHLVALGHQQ 180 181 IALLAGPLSSVSARLRLAGWHKYLTRNQIQPIAEREGDWSAMSGFQQTMQMLNEGIVPTA 240 241 MLVANDQMALGAMRAITESGLRVGADISVVGYDDTEDSSCYIPPLTTIKQDFRLLGQTSV 300 301 DRLLQLSQGQAVKGNQLLPVSLVKRKTTLA |
| Interface Residues: | 5, 6, 15, 16, 17, 18, 20, 21, 27, 28, 29, 52, 55, 56, 63 |
| 3D-footprint Homologues: | 1efa_B, 7ce1_D, 3oqm_C, 5ui5_I, 1l1m_B, 4i2o_B, 1zvv_A, 1jft_A, 1owf_B |
| Binding Motifs: | 1efa_AB TGTGAGCGCTCACAA 1efa_B CGCTCACAA |
| Binding Sites: | 1efa_D 1efa_E |
| Publications: | Bell C.E, Lewis M. A closer view of the conformation of the Lac repressor bound to operator. Nature structural biology 7:209-14 (2000). [Pubmed] |
| Related annotations: | PaperBLAST |
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