Transcription Factor
Accessions: | JDP2_DBD (HumanTF 1.0), JDP2 (HT-SELEX2 May2017) |
Names: | JDP2, JDP2_HUMAN, ENSG00000140044 |
Organisms: | Homo sapiens |
Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
Uniprot: | Q8WYK2 |
Notes: | Ensembl ID: ENSG00000140044; DNA-binding domain sequence; TF family: bZIP; Clone source: Megaman, TF family: bZIP experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: bZIP experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: bZIP experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3, TF family: bZIP experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
Length: | 101 |
Pfam Domains: | 20-78 bZIP transcription factor 21-74 Basic region leucine zipper |
Sequence: (in bold interface residues) | 1 HFLEVKLGKRPQPVKSELDEEEERRKRRREKNKVAAARCRNKKKERTEFLQRESERLELM 60 61 NAELKTQIEELKQERQQLILMLNRHRPTCIVRTDSVKTPES |
Interface Residues: | 28, 29, 32, 33, 35, 36, 39, 40, 43 |
3D-footprint Homologues: | 4eot_A, 1skn_P, 7x5e_E, 2wt7_A, 7x5e_F, 2wt7_B, 1nwq_C, 6mg1_B, 5vpe_D, 5t01_B, 5vpe_C |
Binding Motifs: | JDP2_DBD_1 ATGAsTCAT JDP2_DBD_2 gATGACGTCAyc JDP2_3 srTGACGTCAys JDP2_4 sATGAsTCATs JDP2_7 srTgAyGTmAys JDP2_8 srTGmskCAys JDP2_methyl_1 grTGAyGTCAyc JDP2_methyl_2 gATGAsTCAyc JDP2_methyl_5 srTGAyGTcAys JDP2_methyl_6 srTGAsTCAys |
Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
Related annotations: | PaperBLAST |
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