Transcription Factor
| Accessions: | UP00485A (UniPROBE 20160601) |
| Names: | FLJ53540, KIAA0200, Mam-1, Mam1, MAML 1, MAML-1, MAML1, mastermind-like 1 (Drosophila) |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | mastermind-like 1 (Drosophila): Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation |
| Length: | 62 |
| Pfam Domains: | 2-61 MamL-1 domain |
| Sequence: (in bold interface residues) | 1 LPRHSAVMERLRRRIELCRRHHSTCEARYEAVSPERLELERQHTFALHQRCIQAKAKRAG 60 61 KH |
| Interface Residues: | 36 |
| 3D-footprint Homologues: | 2han_A |
| Binding Motifs: | UP00485A_1 ksmscgTGGGAayswst UP00485A_2 yckwwhscrTGGGAAmywkwkrg UP00485A_3 yykrcaycgTGGGAACcvcdwtg UP00485A_4 tmkrmaycvTGGGAAccmbdwkg UP00485A_5 cwckwwwsCrTGGGAAmhwktkd UP00485A_6 yyckwwhsCgTGGGAAmywytkd UP00485A_7 tykrmwhcvTGGGAAccmswadg |
| Binding Sites: | CGTGTGAA GCGTGGGA AGTTCCCA ATGGGAAA ATGGGAAC ATTCCCAC CATGGGAA CCGTGGGA CCTGGGAA CGTGAGAA CGTGGGAA CGTGGGAG CGTTCCCA CTGGGAAA CTGGGAAC CTTCCCAC CTTTCCCA GATTCCCA GCTCCCAC GGTGGGAA GGTTCCCA GTGGGAAA GTGGGAAC GTTTCCCA TATGGGAA TGGGAAAA TGGGAACA TGTGGGAA |
| Publications: | Del Bianco C, Vedenko A, Choi SH, Berger MF, Shokri L, Bulyk ML, Blacklow SC. Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL. PLoS One : (2010). [Pubmed] |
| Related annotations: | PaperBLAST |
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