Transcription Factor
| Accessions: | UP00585A (UniPROBE 20160601) |
| Names: | B-cell lymphoma 5 protein, B-cell lymphoma 6 protein, BCL-5, BCL-6, BCL5, BCL6_REF, BCL6A, LAZ3, Protein LAZ-3, ZBTB27, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51, ZNF51 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | B-cell lymphoma 6 protein: Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing th |
| Length: | 193 |
| Pfam Domains: | 29-53 Zinc-finger double domain 42-65 C2H2-type zinc finger 43-65 C2H2-type zinc finger 43-65 Zinc finger, C2H2 type 57-81 Zinc-finger double domain 71-91 Zinc-finger of C2H2 type 71-90 C2H2-type zinc finger 71-93 Zinc finger, C2H2 type 71-82 C2H2-type zinc finger 85-109 Zinc-finger double domain 98-109 C2H2-type zinc finger 99-121 Zinc finger, C2H2 type 99-121 C2H2-type zinc finger 113-138 Zinc-finger double domain 127-149 Zinc finger, C2H2 type 127-146 C2H2-type zinc finger 127-149 C2H2-type zinc finger 129-148 Zinc-finger of C2H2 type 142-165 Zinc-finger double domain 155-178 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 TQSEYSDSSCENGAFFCNECDCRFSEEASLKRHTLQTHSDKPYKCDRCQASFRYKGNLAS 60 61 HKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLI 120 121 HTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRHKSQLRLHLRQKHGA 180 181 ITNTKVQYRVSAT |
| Interface Residues: | 26, 28, 29, 32, 53, 54, 55, 56, 57, 59, 60, 62, 63, 64, 66, 71, 81, 82, 83, 84, 85, 87, 88, 91, 92, 109, 110, 111, 112, 113, 115, 116, 137, 138, 139, 140, 141, 142, 143, 144, 145, 147, 148, 165, 166, 167, 168, 169, 170, 171, 172, 173 |
| 3D-footprint Homologues: | 5k5l_F, 1tf6_A, 5v3j_F, 6wmi_A, 7w1m_H, 5yel_A, 1ubd_C, 8cuc_F, 7n5w_A, 2gli_A, 8ssu_A, 6ml4_A, 8gn3_A, 5kkq_D, 1mey_C, 5kl3_A, 8ssq_A, 7eyi_G, 8h9h_G, 2i13_A, 2jpa_A, 2kmk_A, 6jnm_A, 1tf3_A, 5und_A, 1g2f_F, 4x9j_A, 1llm_D, 6blw_A, 6u9q_A, 5ei9_F, 2lt7_A, 7y3m_I, 6e94_A, 7ysf_A, 7y3l_A, 7txc_E, 2drp_D, 1f2i_J, 5yj3_D, 5k5i_A, 6a57_A, 3uk3_C, 2wbs_A, 4m9v_C |
| Binding Motifs: | UP00585A_1 TytwkhTTTCkAGGAAywyaymd |
| Binding Sites: | ACTAGAAA ACTTTCTA CCTAGAAA CCTCGAAA CTAGAAAG CTCGAGGA TAGAAAGA TCCAGGAA TCCTAGAA TCCTCGAA TCGAGGAA TCTAAGAA TCTAGGAA ATTCCTCG ATTCCTGG CCTGGAAA TACTAGAA TCGAAGAA TCTAGTAA TTCCTAAA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.