Transcription Factor
| Accessions: | Q9UL59 (JASPAR 2024) |
| Names: | BAZ-1, BWSCR2-associated zinc finger protein 1, Zinc finger protein 214, ZN214_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9UL59 |
| Length: | 606 |
| Pfam Domains: | 3-43 KRAB box 293-313 Zinc-finger double domain 303-325 Zinc finger, C2H2 type 303-325 C2H2-type zinc finger 303-325 C2H2-type zinc finger 348-368 Zinc-finger double domain 358-380 Zinc finger, C2H2 type 358-380 C2H2-type zinc finger 358-380 C2H2-type zinc finger 376-396 Zinc-finger double domain 385-404 C2H2-type zinc finger 386-408 Zinc finger, C2H2 type 386-408 C2H2-type zinc finger 400-425 Zinc-finger double domain 414-436 C2H2-type zinc finger 414-436 C2H2-type zinc finger 414-436 Zinc finger, C2H2 type 428-453 Zinc-finger double domain 441-464 C2H2-type zinc finger 442-464 C2H2-type zinc finger 442-464 Zinc finger, C2H2 type 456-480 Zinc-finger double domain 469-492 C2H2-type zinc finger 470-492 C2H2-type zinc finger 470-492 Zinc finger, C2H2 type 488-508 Zinc-finger double domain 497-513 C2H2-type zinc finger 498-520 C2H2-type zinc finger 498-520 Zinc finger, C2H2 type 512-537 Zinc-finger double domain 525-548 C2H2-type zinc finger 526-548 Zinc finger, C2H2 type 526-548 C2H2-type zinc finger 543-565 Zinc-finger double domain 554-576 Zinc finger, C2H2 type 554-576 C2H2-type zinc finger 554-576 C2H2-type zinc finger 568-592 Zinc-finger double domain |
| Sequence: (in bold interface residues) | 1 MAVTFEDVTIIFTWEEWKFLDSSQKRLYREVMWENYTNVMSVENWNESYKSQEEKFRYLE 60 61 YENFSYWQGWWNAGAQMYENQNYGETVQGTDSKDLTQQDRSQCQEWLILSTQVPGYGNYE 120 121 LTFESKSLRNLKYKNFMPWQSLETKTTQDYGREIYMSGSHGFQGGRYRLGISRKNLSMEK 180 181 EQKLIVQHSYIPVEEALPQYVGVICQEDLLRDSMEEKYCGCNKCKGIYYWNSRCVFHKRN 240 241 QPGENLCQCSICKACFSQRSDLYRHPRNHIGKKLYGCDEVDGNFHQSSGVHFHQRVHIGE 300 301 VPYSCNACGKSFSQISSLHNHQRVHTEEKFYKIECDKDLSRNSLLHIHQRLHIGEKPFKC 360 361 NQCGKSFNRSSVLHVHQRVHTGEKPYKCDECGKGFSQSSNLRIHQLVHTGEKSYKCEDCG 420 421 KGFTQRSNLQIHQRVHTGEKPYKCDDCGKDFSHSSDLRIHQRVHTGEKPYTCPECGKGFS 480 481 KSSKLHTHQRVHTGEKPYKCEECGKGFSQRSHLLIHQRVHTGEKPYKCHDCGKGFSHSSN 540 541 LHIHQRVHTGEKPYQCAKCGKGFSHSSALRIHQRVHAGEKPYKCREYYKGFDHNSHLHNN 600 601 HRRGNL |
| Interface Residues: | 288, 292, 313, 317, 341, 342, 343, 344, 347, 351, 358, 368, 369, 370, 371, 372, 375, 379, 396, 397, 398, 399, 400, 402, 403, 424, 425, 426, 427, 428, 429, 430, 431, 433, 434, 437, 452, 453, 454, 455, 456, 458, 459, 460, 462, 463, 480, 481, 482, 483, 484, 485, 486, 487, 488, 493, 507, 508, 509, 510, 511, 512, 514, 515, 519, 536, 537, 538, 539, 540, 543, 564, 565, 566, 567, 568, 571 |
| 3D-footprint Homologues: | 7w1m_H, 5yel_A, 8ssq_A, 2kmk_A, 3uk3_C, 1tf3_A, 8cuc_F, 5k5i_A, 5und_A, 8ssu_A, 1tf6_A, 5v3j_F, 2i13_A, 1llm_D, 6u9q_A, 6e94_A, 1ubd_C, 2drp_D, 6ml4_A, 8gn3_A, 6jnm_A, 7y3l_A, 1mey_C, 7txc_E, 6blw_A, 2lt7_A, 7y3m_I, 6a57_A, 2jpa_A, 5kl3_A, 6wmi_A, 5kkq_D, 4m9v_C, 7n5w_A, 1f2i_J, 5yj3_D, 1g2f_F, 5k5l_F, 4x9j_A, 2wbs_A, 5ei9_F, 7eyi_G, 8h9h_G, 7ysf_A, 2gli_A |
| Binding Motifs: | MA1975.1 rttCATcAAkgtCCT MA1975.2 tCATcAAkgtCCT |
| Publications: | Imbeault M, Helleboid PY, Trono D. KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks. Nature 543:550-554 (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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