Transcription Factor

Accessions: 6vvv_F (3D-footprint 20231221)
Names: A0QW02_MYCS2, RNA polymerase sigma factor SigA
Organisms: Mycobacterium smegmatis, Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: A0QW02
Length: 302
Pfam Domains: 1-35 Sigma-70 factor, region 1.2
71-141 Sigma-70 region 2
150-226 Sigma-70 region 3
239-292 Sigma-70, region 4
Sequence:
(in bold interface residues)
1 ADSVRAYLKQIGKVALLNAEEEVELAKRIEAGLYATQKLAELAEKGEKLPVQQRRDMQWI 60
61 CRDGDRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFS 120
121 TYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAKEMD 180
181 ITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSVL 240
241 ETLSEREAGVVRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLR 300
301 DY
Interface Residues: 265, 266, 275, 276, 277, 278, 280, 281
3D-footprint Homologues: 6ido_B, 3n97_A, 8cyf_B
Binding Motifs: 6vvv_F CTTGACAnnnnnnnnnnnnTnTGCT
6vvv_FT AGCAnAnnnnnnnnnnnnTGTCAAG
Binding Sites: 6vvv_O
6vvv_P
Publications: Lilic M, Chen J, Boyaci H, Braffman N, Hubin EA, Herrmann J, Müller R, Mooney R, Landick R, Darst SA, Campbell EA. The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc Natl Acad Sci U S A 117:30423-30432 (2020). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.