Transcription Factor

						

			
Accessions: 6vvv_F (3D-footprint 20231221)

			
Names: A0QW02_MYCS2, RNA polymerase sigma factor SigA
Organisms: Mycobacterium smegmatis, Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: A0QW02
Length: 302
Pfam Domains:      1-35 Sigma-70 factor, region 1.2
   71-141 Sigma-70 region 2 
  150-226 Sigma-70 region 3
  239-292 Sigma-70, region 4
Sequence: 
(in bold interface residues)		   1 ADSVRAYLKQIGKVALLNAEEEVELAKRIEAGLYATQKLAELAEKGEKLPVQQRRDMQWI   60
  61 CRDGDRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFS  120
 121 TYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAKEMD  180
 181 ITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSVL  240
 241 ETLSEREAGVVRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLR  300
 301 DY
Interface Residues: 265, 266, 275, 276, 277, 278, 280, 281
3D-footprint Homologues: 6ido_B, 3n97_A, 8cyf_B
Binding Motifs: 6vvv_F CTTGACAnnnnnnnnnnnnTnTGCT
6vvv_FT AGCAnAnnnnnnnnnnnnTGTCAAG
Binding Sites: 6vvv_O
6vvv_P
			
Publications: Lilic M, Chen J, Boyaci H, Braffman N, Hubin EA, Herrmann J, Müller R, Mooney R, Landick R, Darst SA, Campbell EA. The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc Natl Acad Sci U S A 117:30423-30432 (2020). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
Disclaimer and license


These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.