Transcription Factor
| Accessions: | UP00595A (UniPROBE 20160601) |
| Names: | HHO.C1, Homeobox protein HHO.C1, Homeobox protein Hox-2C, homeobox protein Hox-B7, Hox-2.3, HOX2, HOX2C, HOXB7_REF |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | homeobox protein Hox-B7: This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma. |
| Length: | 90 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 SNFRIYPWMRSSGTDRKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHTLCLTERQI 60 61 KIWFQNRRMKWKKENKTAGPGTTGQDRAEA |
| Interface Residues: | 13, 15, 16, 17, 18, 19, 20, 21, 58, 59, 61, 62, 65, 66, 69, 70, 72, 73 |
| 3D-footprint Homologues: | 1b72_A, 1puf_A, 3a01_E, 6a8r_A, 2h1k_B, 3cmy_A, 5zfz_A, 1fjl_B, 1ig7_A, 1jgg_B, 3lnq_A, 2lkx_A, 6m3d_C, 3d1n_M, 1zq3_P, 1nk2_P, 2ld5_A, 7q3o_C, 5jlw_D, 6es3_K, 4xrs_G, 2hdd_A, 3rkq_B, 2r5y_A, 1puf_B, 5flv_I, 2hos_A, 5zjt_E, 4cyc_A, 7psx_B, 5hod_A, 1e3o_C, 1le8_A, 7xrc_C, 2xsd_C, 1du0_A, 4qtr_D, 8g87_X, 3l1p_A, 1o4x_A |
| Binding Motifs: | UP00595A_1 TdanrbbrTAATTAytrywawww UP00595A_2 ttmyywrrTAATTAyyawtwwA |
| Binding Sites: | GGTAATTA AGTAATTA ATAATTAA ATAATTAC ATAATTAT ATATTATG ATCAATTA ATCATTAA ATTAATAG ATTAATGA ATTAATTA ATTAATTG CATAATTA CATTAATG CGTAATTA GATAATTA GTAATTAA GTAATTAC GTCATTAA TAATATTA TAATTATA TATATATA TATTAATA ACCATTAA ATAATCAT ATTAATGG |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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