Transcription Factor

						

			
Accessions: 1hjb_C (3D-footprint 20231221), 1hjb_F (3D-footprint 20231221), 1io4_C (3D-footprint 20231221)

			
Names: Acute myeloid leukemia 1 protein, CBF-alpha-2, Core-binding factor subunit alpha-2, Oncogene AML-1, PEA2-alpha B, PEBP2-alpha B, Polyomavirus enhancer-binding protein 2 alpha B subunit, RUNT-RELATED TRANSCRIPTION FACTOR 1, RUNX1_MOUSE, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit
Organisms: Mus musculus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q03347
Length: 120
Pfam Domains:     1-120 Runt domain
Sequence: 
(in bold interface residues)		   1 GELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRN   60
  61 ATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRH  120
Interface Residues: 21, 83, 111, 112, 115, 118
3D-footprint Homologues: 4l0y_A, 4l18_E, 6vg8_D, 3wts_A, 6vgd_D
Binding Motifs: 1hjb_ABC TTTCCAAAnnnTGTGGTTG
1hjb_DEF AACCACAnnnTTTGGAAA
1io4_ABC TTTCCAAAnnnTGTGGT
Binding Sites: 1hjb_G / 1hjb_I / 1io4_E
1hjb_H / 1hjb_J / 1io4_F
			
Publications: Tahirov T.H, Inoue-Bungo T, Morii H, Fujikawa A, Sasaki M, Kimura K, Shiina M, Sato K, Kumasaka T, Yamamoto M, Ishii S, Ogata K. Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta. Cell 104:755-67 (2001). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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