Transcription Factor
| Accessions: | 5mez_A (3D-footprint 20231221) |
| Names: | Deletion target in pancreatic carcinoma 4, hSMAD4, MAD homolog 4, MH1 domain of human Smad4, Mothers against decapentaplegic homolog 4, Mothers against DPP homolog 4, SMAD 4, SMAD family member 4, SMAD4_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | Q13485 |
| Length: | 125 |
| Pfam Domains: | 23-123 MH1 domain |
| Sequence: (in bold interface residues) | 1 ACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTI 60 61 QRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHYE 120 121 RVVSP |
| Interface Residues: | 65, 67, 69, 74, 101, 103 |
| 3D-footprint Homologues: | 6fzs_A, 5nm9_A, 5od6_A, 6h3r_A, 5mey_A, 7qd4_A |
| Binding Motifs: | 5mez_A GgCTa |
| Binding Sites: | 5mez_D / 5mez_E |
| Publications: | Martin-Malpartida P, Batet M, Kaczmarska Z, Freier R, Gomes T, Aragón E, Zou Y, Wang Q, Xi Q, Ruiz L, Vea A, Márquez JA, Massagué J, Macias MJ. Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors. Nat Commun 8:2070 (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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