Transcription Factor
| Accessions: | Q147U1 (JASPAR 2024) |
| Names: | ZN846_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q147U1 |
| Length: | 533 |
| Pfam Domains: | 8-47 KRAB box 199-220 Zinc finger, C2H2 type 212-237 Zinc-finger double domain 226-244 C2H2-type zinc finger 226-244 C2H2-type zinc finger 226-248 Zinc finger, C2H2 type 246-265 Zinc-finger double domain 254-266 C2H2-type zinc finger 254-276 C2H2-type zinc finger 254-276 Zinc finger, C2H2 type 269-293 Zinc-finger double domain 281-302 C2H2-type zinc finger 282-304 Zinc finger, C2H2 type 282-300 C2H2-type zinc finger 297-321 Zinc-finger double domain 310-332 C2H2-type zinc finger 310-332 Zinc finger, C2H2 type 310-330 C2H2-type zinc finger 328-348 Zinc-finger double domain 337-352 C2H2-type zinc finger 338-360 C2H2-type zinc finger 338-360 Zinc finger, C2H2 type 353-377 Zinc-finger double domain 365-388 C2H2-type zinc finger 366-388 C2H2-type zinc finger 366-388 Zinc finger, C2H2 type 381-405 Zinc-finger double domain 393-407 C2H2-type zinc finger 394-416 C2H2-type zinc finger 394-416 Zinc finger, C2H2 type 409-433 Zinc-finger double domain 421-444 C2H2-type zinc finger 422-444 C2H2-type zinc finger 422-444 Zinc finger, C2H2 type 437-460 Zinc-finger double domain 451-472 C2H2-type zinc finger 451-472 C2H2-type zinc finger 451-472 Zinc finger, C2H2 type 464-488 Zinc-finger double domain 478-500 C2H2-type zinc finger 478-500 C2H2-type zinc finger 478-500 Zinc finger, C2H2 type 493-516 Zinc-finger double domain 505-526 C2H2-type zinc finger 506-527 Zinc finger, C2H2 type 506-527 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MDSSQHLVTFEDVAVDFTQEEWTLLDQAQRDLYRDVMLENYKNLIILAGSELFKRSLMSG 60 61 LEQMEELRTGVTGVLQELDLQLKTKGSPLLQDISAERSPNGVQLERSNTAEKLYDSNHSG 120 121 KVFNEHPFLMTHMITHIGEKTSEDNQSGKALRKNFPHSFYKKSHAEGKMPKCVKHEKAFN 180 181 QFPNLTRQNKTHTQEKLCECKDCWRTFLNQSSLKLHIRSHNGDKHYVCKECGKAFSNSSH 240 241 LIGHGRIHSGEKPYVCKECGKAFTQSTGLKLHIRTHSGEKPYKCKECGKAFTHSSYLTDH 300 301 TRIHSGKKPYVCMECGKAFTRSTGLILHMRIHTGEKPYECKECGKAFIHSSYLTKHVRIH 360 361 SGEKLYLCKACGKAFTRSSGLVLHMRTHTGEKPYECKECGKAFNNSSMLSQHVRIHTGEK 420 421 PYECKECGKAFTQSSGLSTHLRTHTGEKACECKECGKAFARSTNLNMHMRTHTGEKPYAC 480 481 KECGKAFRYSTYLNVHTRTHTGAKPYECKKCGKNFTQSSALAKHLRTKACEKT |
| Interface Residues: | 209, 211, 212, 215, 236, 237, 239, 240, 243, 264, 265, 267, 268, 271, 292, 293, 294, 295, 296, 298, 299, 303, 320, 321, 322, 323, 324, 326, 327, 331, 349, 350, 351, 352, 355, 366, 376, 377, 378, 379, 380, 382, 383, 384, 385, 386, 389, 404, 405, 406, 407, 408, 409, 410, 411, 412, 414, 433, 434, 435, 436, 438, 439, 443, 445, 459, 460, 461, 462, 463, 464, 466, 467, 471, 488, 489, 490, 491, 492, 493, 494, 495, 496, 497, 499, 516, 517, 518, 519, 520, 522, 523 |
| 3D-footprint Homologues: | 6wmi_A, 8cuc_F, 5ei9_F, 7w1m_H, 6a57_A, 6e94_A, 7ysf_A, 2drp_D, 5yj3_D, 8ssq_A, 8ssu_A, 5v3j_F, 5kkq_D, 2lt7_A, 6ml4_A, 2i13_A, 5und_A, 5yel_A, 1ubd_C, 2kmk_A, 6jnm_A, 1tf6_A, 6blw_A, 4m9v_C, 2jpa_A, 7y3l_A, 7n5w_A, 4x9j_A, 8gn3_A, 2wbs_A, 6u9q_A, 1mey_C, 5kl3_A, 1f2i_J, 5k5i_A, 8h9h_G, 5k5l_F, 1llm_D, 7txc_E, 2gli_A, 1g2f_F, 7eyi_G, 1tf3_A, 7y3m_I, 3uk3_C |
| Binding Motifs: | UN0663.1 ssTCCCGGGAss UN0663.2 TCCCGGGA |
| Binding Sites: | UN0663.2.11 / UN0663.2.19 / UN0663.2.8 / UN0663.2.9 UN0663.2.6 UN0663.1.1 UN0663.1.10 UN0663.1.11 UN0663.1.12 UN0663.1.13 UN0663.1.14 UN0663.1.15 UN0663.1.16 UN0663.1.17 UN0663.1.18 UN0663.1.19 UN0663.1.2 UN0663.1.20 UN0663.1.3 UN0663.1.4 UN0663.1.5 UN0663.1.6 UN0663.1.7 UN0663.1.8 UN0663.1.9 UN0663.2.17 UN0663.2.1 UN0663.2.10 / UN0663.2.12 / UN0663.2.20 / UN0663.2.7 UN0663.2.13 / UN0663.2.15 / UN0663.2.4 UN0663.2.14 / UN0663.2.16 / UN0663.2.3 UN0663.2.18 UN0663.2.2 UN0663.2.5 |
| Related annotations: | PaperBLAST |
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