Transcription Factor

Accessions: 3ikt_A (3D-footprint 20231221)
Names: Redox-sensing transcriptional repressor rex, REX_THET2
Organisms: strain HB27 / ATCC BAA-163 / DSM 7039, Thermus thermophilus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q72I39
Length: 204
Pfam Domains: 3-51 Putative DNA-binding protein N-terminus
77-172 CoA binding domain
Sequence:
(in bold interface residues)
1 GMKVPEAAISRLITYLRILEELEAQGVHRTSSEQLGELAQVTAFQVRKDLSYFGSYGTGY 60
61 TVPVLKRELRHILGLNRKWGLCIVGMGRLGSALADYPGFGESFELRGFFDVDPEKVGRPV 120
121 RGGVIEHVDLLPQRVPGRIEIALLTVPREAAQKAADLLVAAGIKGILNFAPVVLEVPKEV 180
181 AVENVDFLAGLTRLSFAILNPKWR
Interface Residues: 44, 45, 47, 48, 51, 52, 56, 58, 61, 67, 68, 70, 71, 72, 74, 75
3D-footprint Homologues: 3ikt_B, 7wb3_B, 3ket_A, 3wgi_D, 3l2c_A, 3co6_C
Binding Motifs: 3ikt_AB TGTGAnnnnnnTCACAGC
Publications: McLaughlin K.J, Strain-Damerell C.M, Xie K, Brekasis D, Soares A.S, Paget M.S, Kielkopf C.L. Structural basis for NADH/NAD+ redox sensing by a Rex family repressor. Molecular cell 38:563-75 (2010). [Pubmed]
Related annotations: PaperBLAST

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