Transcription Factor
| Accessions: | UP00153A (UniPROBE 20160601) |
| Names: | Bft, Hindlimb expressed homeobox protein backfoot, Homeobox protein P-OTX, paired-like homeodomain transcription factor 1, Pituitary homeobox 1, Pituitary OTX-related factor, Pitx1, Potx, Ptx1 |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P70314 |
| Description: | paired-like homeodomain transcription factor 1 |
| Length: | 93 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 AGCGGGAEDPAKKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSMREEIAVWTNLTEPRV 60 61 RVWFKNRRAKWRKRERNQQLDLCKGGYVPQFSG |
| Interface Residues: | 15, 16, 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73, 74 |
| 3D-footprint Homologues: | 1qum_A, 3d1n_M, 1ig7_A, 5zfz_A, 1puf_A, 2h1k_B, 6a8r_A, 3cmy_A, 1fjl_B, 1zq3_P, 6m3d_C, 1jgg_B, 3lnq_A, 2lkx_A, 1nk2_P, 2ld5_A, 6es3_K, 1b72_A, 4xrs_G, 2hos_A, 5flv_I, 3l1p_A, 5zjt_E, 3a01_E, 7psx_B, 5hod_A, 1puf_B, 1au7_A, 2hdd_A, 7q3o_C, 3rkq_B, 2r5y_A, 5jlw_D, 1le8_A, 7xrc_C, 2xsd_C, 4j19_B, 1e3o_C, 1o4x_A, 4cyc_A, 1le8_B, 1du0_A, 8g87_X, 1mnm_C, 1k61_B, 4qtr_D |
| Binding Motifs: | UP00153A_1 tkrrrGGGATTAAmaah |
| Binding Sites: | ACTAATCC AGGATTAA AGGATTAG AGGGATTA ATAATCCC ATTAATCC CCGGATTA CGGATTAA CGGGATTA CTAATCCC CTTAATCC GAGGATTA GCTAATCC GGATTAAA GGATTAAC GGATTATA GGGGATTA GTGGATTA TAATCCCA TGGATTAA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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