Transcription Factor
| Accessions: | GCM2 (HT-SELEX2 May2017), O75603 (JASPAR 2024) |
| Names: | ENSG00000124827, GCM2, Chorion-specific transcription factor GCMb, GCM motif protein 2, GCM2_HUMAN, Glial cells missing homolog 2, hGCMb |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1, JASPAR 2024 2 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | TF family: GCM experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: GCM experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 506 |
| Pfam Domains: | 35-173 GCM motif protein |
| Sequence: (in bold interface residues) | 1 MPAAAVQEAVGVCSYGMQLSWDINDPQMPQELALFDQFREWPDGYVRFIYSSDEKKAQRH 60 61 LSGWAMRNTNNHNGHILKKSCLGVVVCTQACTLPDGSRLQLRPAICDKARLKQQKKACPN 120 121 CHSALELIPCRGHSGYPVTNFWRLDGNAIFFQAKGVHDHPRPESKSETEARRSAIKRQMA 180 181 SFYQPQKKRIRESEAEENQDSSGHFSNIPPLENPEDFDIVTETSFPIPGQPCPSFPKSDV 240 241 YKATCDLATFQGDKMPPFQKYSSPRIYLPRPPCSYELANPGYTNSSPYPTLYKDSTSIPN 300 301 DTDWVHLNTLQCNVNSYSSYERSFDFTNKQHGWKPALGKPSLVERTNHGQFQAMATRPYY 360 361 NPELPCRYLTTPPPGAPALQTVITTTTKVSYQAYQPPAMKYSDSVREVKSLSSCNYAPED 420 421 TGMSVYPEPWGPPVTVTRAASPSGPPPMKIAGDCRAIRPTVAIPHEPVSSRTDEAETWDV 480 481 CLSGLGSAVSYSDRVGPFFTYNNEDF |
| Interface Residues: | 68, 69, 70, 72, 93, 105 |
| 3D-footprint Homologues: | 1odh_A, 4hc9_A |
| Binding Motifs: | MA0767.1 bATGCGGGyr UN0551.1 rTrsGGGtaATTag GCM2_2 RTGCGGGyr GCM2_methyl_1 ATRcgGGyr MA0767.2 ATGCGGGy UN0551.2 rTrsGGGtaATTa |
| Publications: | Akiyama Y., Hosoya T., Poole A. M., Hotta Y. The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals. Proc. Natl. Acad. Sci. USA 93:14912-14916 (1996). [Pubmed] |
| Related annotations: | PaperBLAST |
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