Transcription Factor
| Accessions: | DMRTA1 (HT-SELEX2 May2017), Q5VZB9 (JASPAR 2024) |
| Names: | DMRTA1, ENSG00000176399, DMRTA_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1, JASPAR 2024 2 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | TF family: DM experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: DM experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 504 |
| Pfam Domains: | 93-139 DM DNA binding domain 327-364 DMRTA motif |
| Sequence: (in bold interface residues) | 1 MERSQCGSRDRGVSGRPHLAPGLVVAAPPPPSPALPVPSGMQVPPAFLRPPSLFLRAAAA 60 61 AAAAAAATSGSGGCPPAPGLESGVGAVGCGYPRTPKCARCRNHGVVSALKGHKRFCRWRD 120 121 CACAKCTLIAERQRVMAAQVALRRQQAQEESEARGLQRLLCSGLSWPPGGRASGGGGRAE 180 181 NPQSTGGPAAGAALGLGALRQASGSATPAFEVFQQDYPEEKQEQKESKCESCQNGQEELI 240 241 SKSHQLYLGSSSRSNGVIGKQSIGSSISEYSNKPDSILSPHPGEQSGGEESPRSLSSSDL 300 301 ESGNESEWVKDLTATKASLPTVSSRPRDPLDILTKIFPNYRRSRLEGILRFCKGDVVQAI 360 361 EQVLNGKEHKPDNRNLANSEELENTAFQRASSFSLAGIGFGTLGNKSAFSPLQTTSASYG 420 421 GDSSLYGVNPRVGISPLRLAYSSAGRGLSGFMSPYLTPGLVPTLPFRPALDYAFSGMIRD 480 481 SSYLSSKDSITCGRLYFRPNQDNP |
| Interface Residues: | 93, 132, 136, 139, 140, 143, 144 |
| 3D-footprint Homologues: | 4yj0_C |
| Binding Motifs: | DMRTA1_2 / MA1707.1 / UN0115.1 aattGwTACAwt DMRTA1_methyl_1 aattGwTACAtt MA1707.2 ttGwTACAwt |
| Publications: | Murphy M. W., Zarkower D., Bardwell V. J. Vertebrate DM domain proteins bind similar DNA sequences and can heterodimerize on DNA.. BMC Mol. Biol. 8:58 (2007). [Pubmed] |
| Related annotations: | PaperBLAST |
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