Transcription Factor

						

			
Accessions: IRF8_full (HumanTF 1.0)

			
Names: H-ICSBP, Interferon consensus sequence-binding protein, Interferon regulatory factor 8, IRF-8, IRF8, IRF8_HUMAN
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: Q02556
Notes: Ensembl ID: ENSG00000140968; Full protein sequence; TF family: IRF; Clone source: hORFeome
Length: 427
Pfam Domains:     9-114 Interferon regulatory factor transcription factor
  203-381 Interferon-regulatory factor 3
Sequence: 
(in bold interface residues)		   1 MCDRNGGRRLRQWLIEQIDSSMYPGLIWENEEKSMFRIPWKHAGKQDYNQEVDASIFKAW   60
  61 AVFKGKFKEGDKAEPATWKTRLRCALNKSPDFEEVTDRSQLDISEPYKVYRIVPEEEQKC  120
 121 KLGVATAGCVNEVTEMECGRSEIDELIKEPSVDDYMGMIKRSPSPPEACRSQLLPDWWAQ  180
 181 QPSTGVPLVTGYTTYDAHHSAFSQMVISFYYGGKLVGQATTTCPEGCRLSLSQPGLPGTK  240
 241 LYGPEGLELVRFPPADAIPSERQRQVTRKLFGHLERGVLLHSSRQGVFVKRLCQGRVFCS  300
 301 GNAVVCKGRPNKLERDEVVQVFDTSQFFRELQQFYNSQGRLPDGRVVLCFGEEFPDMAPL  360
 361 RSKLILVQIEQLYVRQLAEEAGKSCGAGSVMQAPEEPPPDQVFRMFPDICASHQRSFFRE  420
 421 NQQITV*
Interface Residues: 42, 44, 76, 80, 81, 83, 84, 87, 88
3D-footprint Homologues: 1if1_B, 2o61_A, 2pi0_B, 2irf_L, 7oot_B
Binding Motifs: IRF8_full yCGAAACCGAAACT
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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