Transcription Factor
| Accessions: | Q61321 (JASPAR 2024) |
| Names: | Homeobox protein SIX4, Sine oculis homeobox homolog 4, SIX4_MOUSE, Skeletal muscle-specific ARE-binding protein AREC3 |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 775 |
| Pfam Domains: | 223-272 Homeobox domain 239-270 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 MSSSSPTGQIASAADIKQENGMESASEGQEAHREVAGGAAAGLSPPAPAPFPLEPGDAAA 60 61 ASRVSREEGAAAAGAADQVQLHSELLGRHQHAAAAQPPLAFSPDHVACVCEALQQGGNLD 120 121 RLARFLWSLPQSDLLRGNESLLKARALVAFHQGIYPELYSILESHSFESANHPLLQQLWY 180 181 KARYTEAERARGRPLGAVDKYRLRRKFPLPRTIWDGEETVYCFKEKSRNALKELYKQNRY 240 241 PSPAEKRHLAKITGLSLTQVSNWFKNRRQRDRNPSETQSKSESDGNPSTEDESSKGHEDL 300 301 SPHPLSGASDGVTNLSLSSHVEPVYMQQIGNAKISLSSSGVLLNGSLVPASTSPVFLNGN 360 361 SFIQGHNGVILNGLNVGNTQTVSLNPPKMSSNIVGNGIAMTDILGSTSQDVKEFKVLQSS 420 421 AVNSAATTSYSPSAPVSFPGLIPCTEVKREGIQTVASQDGGSVVTFTTPVQINQYGIVQI 480 481 PNSGANGQFLNGSIGFSPLQLPPVSVAASQGNLSVTPSTSDGSTFTSEPATVQHGKLFLS 540 541 PLTPSAVVYTVPNSGQTVGAVKQEGLERGLVFSQLMPVNHSAQVNASLSSENLSGSGLHP 600 601 LTSSLVNVSAAHGFSLTPPTLLNPTELNPDLAESQPVSAPVASKCTVSSVSNTNYATLQN 660 661 CSLIPGQDLLSGPMTQAALGEIVPTAEEQVSHASTAVHQDFVREQRLVLQSVPNIKENFL 720 721 QNSENKATNNLMMLDSKSKYVLDGMVEAGCEDLGTDKKELAKLQTVQLDEDMQDL |
| Interface Residues: | 121, 124, 178, 181, 182, 185, 204, 211, 258, 259, 261, 262, 265, 266, 269, 270, 272, 276 |
| 3D-footprint Homologues: | 5zfz_A, 4xrs_G, 2ld5_A, 5jlw_D, 4j19_B, 1le8_A, 1ig7_A, 7q3o_C, 1e3o_C, 1au7_A, 1nk2_P, 6wig_A, 1fjl_B, 2r5y_A, 1zq3_P, 6fqp_B, 1b72_A, 5flv_I, 3lnq_A, 1o4x_A, 7psx_B, 5zjt_E, 4qtr_D, 3a01_E, 2d5v_B, 1le8_B, 6fqq_E, 1du0_A, 5hod_A, 3rkq_B, 1puf_A, 1jgg_B, 6a8r_A, 4xrm_B, 3cmy_A, 2h1k_B, 1mnm_C, 4cyc_A, 2lkx_A, 1puf_B, 8g87_X, 1k61_B, 6es3_K, 3l1p_A, 2hdd_A, 2hos_A, 6m3d_C |
| Binding Motifs: | PH0164.1 atrmaTGACACCthybr MA2001.1 gwAACCTGAbm MA2001.2 AACCTGA |
| Binding Sites: | MA2001.1.1 / MA2001.1.2 MA2001.1.10 / MA2001.1.14 MA2001.1.11 / MA2001.1.15 MA2001.1.12 / MA2001.1.17 MA2001.1.13 / MA2001.1.18 MA2001.1.14 / MA2001.1.19 MA2001.1.15 / MA2001.1.20 MA2001.1.16 MA2001.1.17 MA2001.1.18 MA2001.1.19 MA2001.1.2 / MA2001.1.3 MA2001.1.20 MA2001.1.3 / MA2001.1.4 MA2001.1.4 / MA2001.1.7 MA2001.1.5 / MA2001.1.8 MA2001.1.6 / MA2001.1.9 MA2001.1.11 / MA2001.1.7 MA2001.1.12 / MA2001.1.8 MA2001.1.13 / MA2001.1.9 MA2001.2.7 MA2001.2.14 MA2001.1.1 MA2001.1.10 MA2001.1.16 MA2001.1.5 MA2001.1.6 MA2001.2.1 MA2001.2.10 / MA2001.2.11 / MA2001.2.15 MA2001.2.12 / MA2001.2.19 / MA2001.2.8 / MA2001.2.9 MA2001.2.13 / MA2001.2.16 / MA2001.2.20 / MA2001.2.3 / MA2001.2.4 / MA2001.2.6 MA2001.2.17 MA2001.2.18 / MA2001.2.2 MA2001.2.5 |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] Himeda CL, Ranish JA, Angello JC, Maire P, Aebersold R, Hauschka SD. Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer. Mol Cell Biol 24:2132-43 (2004). [Pubmed] |
| Related annotations: | PaperBLAST |
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