Transcription Factor
| Accessions: | UP00597C (UniPROBE 20160601) |
| Names: | BDE, BDSD, Homeobox protein Hox-4I, homeobox protein Hox-D13, HOX4I, HOXD13_I322L, SPD |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | homeobox protein Hox-D13: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entir |
| Length: | 81 |
| Pfam Domains: | 15-71 Homeobox domain 41-67 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 VALNQPDMCVYRRGRKKRVPYTKLQLKELENEYAINKFINKDKRRRISAATNLSERQVTL 60 61 WFQNRRVKDKKIVSKLKDTVS |
| Interface Residues: | 15, 16, 17, 18, 23, 26, 56, 57, 59, 60, 63, 64, 67, 68, 71 |
| 3D-footprint Homologues: | 3cmy_A, 2h1k_B, 1puf_A, 1ig7_A, 6a8r_A, 5zfz_A, 1fjl_B, 2lkx_A, 1nk2_P, 1zq3_P, 6m3d_C, 7q3o_C, 6es3_K, 2ld5_A, 5flv_I, 1b72_A, 5zjt_E, 4gnx_Z, 7psx_B, 5hod_A, 3lnq_A, 2hdd_A, 2r5y_A, 1puf_B, 1jgg_B, 5jlw_D, 3rkq_B, 2hos_A, 4xrs_G, 3a01_E, 4cyc_A, 1le8_A, 1e3o_C, 1au7_A, 1mnm_C, 1du0_A, 4qtr_D, 1k61_B, 1o4x_A |
| Binding Motifs: | UP00597C_1 hmdywrsCTCGTWAAatmwtwa UP00597C_2 yhgyarssTCGTAAAatywtma |
| Binding Sites: | ATCGTAAA ATCGTTAA ATTTACGA CTCGTAAA CTCGTTAA GTCGTAAA GTTTACGA TCGTAAAA TCGTTAAA ATTGTAAA ATTTACAA CTTGTAAA CTTGTTAA CTTTACGA GCTCGTAA GTTAACGA GTTGTAAA TAGTAAAA TCTCGTAA TTGTAAAA TTGTTAAA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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