Transcription Factor

						

			
Accessions: ETS1_DBD (HumanTF 1.0)

			
Names: ETS1, ETS1_HUMAN, p54, Protein C-ets-1
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: P14921
Notes: Ensembl ID: ENSG00000134954; DNA-binding domain sequence; TF family: ETS; Clone source: Gene synthesis
Length: 405
Pfam Domains:    19-100 Sterile alpha motif (SAM)/Pointed domain
  300-381 Ets-domain
Sequence: 
(in bold interface residues)		   1 LLTPSSKEMMSQALKATFSGFTKEQQRLGIPKDPRQWTETHVRDWVMWAVNEFSLKGVDF   60
  61 QKFCMNGAALCALGKDCFLELAPDFVGDILWEHLEILQKEDVKPYQVNGVNPAYPESRYT  120
 121 SDYFISYGIEHAQCVPPSEFSEPSFITESYQTLHPISSEELLSLKYENDYPSVILRDPLQ  180
 181 TDTLQNDYFAIKQEVVTPDNMCMGRTSRGKLGGQDSFESIESYDSCDRLTQSWSSQSSFN  240
 241 SLQRVPSYDSFDSEDYPAALPNHKPKGTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPI  300
 301 QLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRY  360
 361 YYDKNIIHKTAGKRYVYRFVCDLQSLLGYTPEELHAMLDVKPDAD
Interface Residues: 297, 352, 353, 355, 356, 357, 359, 360, 374
3D-footprint Homologues: 3zp5_A, 4mhg_A, 8smh_F, 4uno_A, 2stt_A, 8smj_F, 7jsa_J, 3jtg_A, 1dux_F, 8ee9_F, 1yo5_C, 4iri_A, 1awc_A, 4l18_B, 1bc8_C, 4lg0_B
Binding Motifs: ETS1_DBD_1 ACCGGAWrTr
ETS1_DBD_2 aCCGGAwryrCwTCCGgt
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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