Transcription Factor

						

			
Accessions: 6psr_L (3D-footprint 20231221)

			
Names: RNA polymerase sigma factor RpoD, RPOD_ECOLI, Sigma-70
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P00579
Length: 548
Pfam Domains:      2-68 Sigma-70 factor, region 1.1
   83-114 Sigma-70 factor, region 1.2
  125-156 Sigma-70, non-essential region
  155-283 Sigma-70, non-essential region
  314-384 Sigma-70 region 2 
  393-469 Sigma-70 region 3
  482-535 Sigma-70, region 4
Sequence: 
(in bold interface residues)		   1 SQLKLLVTRGKEQGYLTYAEVNDHLPEDIVDSDQIEDIIQMINDMGIQVMEELMLAENTA   60
  61 DEDAAEAAAQVLSSVESEIGRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQC  120
 121 SVAEYPEAITYLLEQYDRVEAEEARLSDLITGFVDPELAREKFAELRAQYVVTRDTIATA  180
 181 QEEILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKLCVEQCKMPKKNFITL  240
 241 FTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRALQKLQQIEEETGLTIEQVKDINRRM  300
 301 SIGEAKARRAKKEMVEANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGY  360
 361 KFSTYATWWIRQAITRSIADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAE  420
 421 RMLMPEDKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTESLRAATH  480
 481 DVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQIEAKALRKLRHPSRSE  540
 541 VLRSFLDD
Interface Residues: 187, 197, 199, 200, 202, 203, 508, 509, 518, 519, 520, 521, 523, 524
3D-footprint Homologues: 3h0d_A, 3n97_A, 6ido_B, 8cyf_B
Binding Motifs: 6psr_L TGTCaaT
Binding Sites: 6psr_O
6psr_P
			
Publications: Chen J, Chiu C, Gopalkrishnan S, Chen AY, Olinares PDB, Saecker RM, Winkelman JT, Maloney MF, Chait BT, Ross W, Gourse RL, Campbell EA, Darst SA. Stepwise Promoter Melting by Bacterial RNA Polymerase. Mol Cell 78:275-288 (2020). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.