Transcription Factor
| Accessions: | UP00373A (UniPROBE 20160601) |
| Names: | MXL-1 |
| Organisms: | Caenorhabditis elegans |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P90982 |
| Description: | MaX-Like: mxl-1 encodes a basic helix-loop-helix protein similar to the vertebrate MAX transcriptional regulators; in vitro, MXL-1 can heterodimerize, and bind an E-box DNA sequence, with MDL-1, a C. elegans MAD-like bHLH protein; mxl-1::gfp reporter fusions are expressed in the posterior intestine and in head and tail neurons. |
| Length: | 123 |
| Pfam Domains: | 30-80 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 SDMSDLEDDQTGHCGSGEHSGPFDPKRHAREQHNALERRRRDNIKDMYTSLREVVPDANG 60 61 ERVQASRAVILKKAIESIEKGQSDSATLSVDVAEQESKNAKLREEIARLKAKKDPSSSQS 120 121 IIQ |
| Interface Residues: | 32, 33, 34, 36, 37, 40, 41, 67 |
| 3D-footprint Homologues: | 1an4_A, 7rcu_E, 5gnj_I, 6g1l_A, 4h10_A, 7ssa_L, 5i50_B, 7d8t_A, 4zpk_A, 5nj8_D, 1am9_A, 7f2f_B, 5eyo_A, 7xi3_A, 5v0l_A, 8osl_P, 7xhv_B, 7xi3_B |
| Binding Motifs: | UP00373A_1 awwAarAAACAwws UP00373A_2 twdasCACGTGskawb |
| Binding Sites: | AACACGTG ACACGTGC ACACGTGG ACCACGTG AGCACGTG ATCACGTG CACGTGAC CACGTGCA CACGTGCC CACGTGCG CACGTGGA CACGTGGC CACGTGGG CACGTGTC CCACGTGA CCACGTGC CCACGTGG GCACGTGA GCACGTGC TCACGTGA |
| Publications: | Grove C.A, De Masi F, Barrasa M.I, Newburger D.E, Alkema M.J, Bulyk M.L, Walhout A.J. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell 138:314-27 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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