Transcription Factor

Accessions: UP00455A (UniPROBE 20160601)
Names: ACA2, Chromosome STability, Cst6, SHF1
Organisms: Saccharomyces cerevisiae
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Description: Chromosome STability : Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability
Length: 64
Pfam Domains: 3-61 bZIP transcription factor
8-52 Basic region leucine zipper
Sequence:
(in bold interface residues)
1 TTAWKRARLLERNRIAASKCRQRKKVAQLQLQKEFNEIKDENRILLKKLNYYEKLISKFK 60
61 KFSK
Interface Residues: 13, 14, 16, 17, 20, 21
3D-footprint Homologues: 5vpe_D, 2wt7_A, 6mg1_B, 5t01_B, 7x5e_F, 5vpe_C
Binding Motifs: UP00455A_1 / UP00455A_2 maghygaTGACGTCAyyrtccw
UP00455A_3 rTGACGTkyr
Binding Sites: CTACGTCA
TGACGTAA
TGACGTCA
TGACATCA
AATGACGT
ACGTCACC
ACGTCACT
ACGTCATA
ACGTCATC
ACGTCATG
ATGACGTA
ATGACGTC
ATGACGTG
ATTACGTA
GTACGTCA
GTGACGTA
TTACGTAA
ATACGTCA
CGACGTCA
GACGTCAC
Publications: Gordân R, Murphy KF, McCord RP, Zhu C, Vedenko A, Bulyk ML. Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. Genome Biol : (2011). [Pubmed]
Related annotations: PaperBLAST

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