Transcription Factor
| Accessions: | 3iv5_A (3D-footprint 20231221), 3jr9_A (3D-footprint 20231221), 3jra_A (3D-footprint 20231221), 3jrb_A (3D-footprint 20231221), 3jrc_A (3D-footprint 20231221), 3jrd_A (3D-footprint 20231221), 3jre_A (3D-footprint 20231221), 3jrf_A (3D-footprint 20231221), 3jrg_A (3D-footprint 20231221), 3jrh_A (3D-footprint 20231221), 3jri_A (3D-footprint 20231221), 4ihv_A (3D-footprint 20231221), 4ihw_A (3D-footprint 20231221), 4ihx_A (3D-footprint 20231221), 4ihy_A (3D-footprint 20231221), 5ds9_A (3D-footprint 20231221), 5dtd_A (3D-footprint 20231221), 5e3l_A (3D-footprint 20231221), 5e3m_A (3D-footprint 20231221), 5e3n_A (3D-footprint 20231221), 5e3o_A (3D-footprint 20231221) |
| Names: | DNA-binding protein fis, Factor-for-inversion stimulation protein, FIS_ECOLI, Hin recombinational enhancer-binding protein |
| Organisms: | Escherichia coli, strain K12 |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P0A6R3 |
| Length: | 91 |
| Pfam Domains: | 48-88 Bacterial regulatory protein, Fis family |
| Sequence: (in bold interface residues) | 1 SDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEQPLLDMVM 60 61 QYTRGNQTRAALMMGINRGTLRKKLKKYGMN |
| Interface Residues: | 77, 78, 80, 82, 83 |
| 3D-footprint Homologues: | 5ds9_A |
| Binding Motifs: | 3iv5_AB TGTnTGnnnnnTGnGCA 3jr9_AB TGTnGAnnnnnTCnGCA 3jra_AB TAgntAnnnnnTGncCA 3jrb_AB TGTnTGnnnnTTGnGCA 3jrc_AB TGnnTgnnnnntCngCA 3jrd_AB TGCnCAnnnnnCAnACA 3jre_AB TGTntGnnnnnTgnGCA 3jrf_AB TGTnAGnnnnnTCnGCA 3jrg_AB TGTnGGnnnnnTCnGCA 3jrh_AB TGTnAcnnnnngGnGCA 3jri_AB TGnnannnnnnncnGCA 4ihv_AB TGtnTGnnnnnTrnnCA 4ihw_AB TGtnngnnnnnTrnnCA 4ihx_AB TGCnCAnnnnCAAAC 4ihy_AB TGCnyAnnnnnCrnaCA 5ds9_A AGCnCA 5ds9_AB AGCnCAnnnnnCAnACT 5dtd_A TgngCG 5dtd_AB CGTnnGnnnnnTCngCG 5e3l_AB GGCnCAnnnnnCAnACC 5e3m_A AGCnCG 5e3m_AB AGCnCGnnnnnCAnACT 5e3n_AB TGCngAnnnnnCcnACA 5e3o_AB TGGnGGnnnnnTcnCCA |
| Binding Sites: | 5dtd_C 5dtd_D 5e3m_C 5e3m_D 5ds9_C 5ds9_D |
| Publications: | Stella S, Cascio D, Johnson R.C. The shape of the DNA minor groove directs binding by the DNA-bending protein Fis. Genes & development 24:814-26 (2010). [Pubmed] Hancock S.P, Ghane T, Cascio D, Rohs R, Di Felice R, Johnson R.C. Control of DNA minor groove width and Fis protein binding by the purine 2-amino group. Nucleic acids research 41:6750-60 (2013). [Pubmed] Hancock SP, Stella S, Cascio D, Johnson RC. DNA Sequence Determinants Controlling Affinity, Stability and Shape of DNA Complexes Bound by the Nucleoid Protein Fis. PLoS One : (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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