Transcription Factor
| Accessions: | RFX2_DBD (HumanTF 1.0), RFX2 (HT-SELEX2 May2017) |
| Names: | DNA-binding protein RFX2, Regulatory factor X 2, RFX2, RFX2_HUMAN, ENSG00000087903 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | P48378 |
| Notes: | Ensembl ID: ENSG00000087903; DNA-binding domain sequence; TF family: RFX; Clone source: Gene synthesis, TF family: RFX experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: RFX experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2 |
| Length: | 149 |
| Pfam Domains: | 58-123 RFX DNA-binding domain |
| Sequence: (in bold interface residues) | 1 SPIVSSAGAYLIHGGMDSTRHSLAHTSRSSPATLEMAIENLQKSEGITSHKSGLLNSHLQ 60 61 WLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTRRLGTRG 120 121 NSKYHYYGIRLKPDSPLNRLQEDTQYMAM |
| Interface Residues: | 98, 102, 115, 119, 124 |
| 3D-footprint Homologues: | 1dp7_P |
| Binding Motifs: | RFX2_DBD_1 sGTTrCCATGGyAACs RFX2_DBD_2 sGTTGCTArGCAACs RFX2_2 sGTtryyATrryaACs RFX2_methyl_1 sGTTrCCATGGyAACg |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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