Transcription Factor
| Accessions: | HXA1_HUMAN (HOCOMOCO 10), P49639 (JASPAR 2024) |
| Names: | Homeobox protein Hox-1F, Homeobox protein Hox-A1, HXA1_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 335 |
| Pfam Domains: | 233-286 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MDNARMNSFLEYPILSSGDSGTCSARAYPSDHRITTFQSCAVSANSCGGDDRFLVGRGVQ 60 61 IGSPHHHHHHHHHHPQPATYQTSGNLGVSYSHSSCGPSYGSQNFSAPYSPYALNQEADVS 120 121 GGYPQCAPAVYSGNLSSPMVQHHHHHQGYAGGAVGSPQYIHHSYGQEHQSLALATYNNSL 180 181 SPLHASHQEACRSPASETSSPAQTFDWMKVKRNPPKTGKVGEYGYLGQPNAVRTNFTTKQ 240 241 LTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREKEGLLPISPATP 300 301 PGNDEKAEESSEKSSSSPCVPSPGSSTSDTLTTSH |
| Interface Residues: | 231, 233, 234, 235, 271, 272, 274, 275, 278, 279, 282, 283, 286 |
| 3D-footprint Homologues: | 2lkx_A, 1zq3_P, 2h1k_B, 7psx_B, 1b72_A, 5hod_A, 3lnq_A, 1puf_A, 1ig7_A, 6a8r_A, 3cmy_A, 2hdd_A, 7q3o_C, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 1jgg_B, 6es3_K, 4xrs_G, 3d1n_M, 2hos_A, 5zfz_A, 4cyc_A, 6m3d_C, 5flv_I, 2ld5_A, 1fjl_B, 5zjt_E, 3a01_E, 1nk2_P, 4j19_B, 1le8_A, 7xrc_C, 1e3o_C, 2xsd_C, 1au7_A, 4qtr_D, 1mnm_C, 1du0_A, 1k61_B, 3l1p_A, 1o4x_A, 8g87_X |
| Binding Motifs: | MA1931.1 aCCGGAAGTAAtTa MA1495.1 sTAATtAs HXA1_HUMAN.H10MO.C|M01237 wkGATKGATg MA1495.2 TAATtA |
| Publications: | Pearson JC, Lemons D, McGinnis W. Modulating Hox gene functions during animal body patterning. Nat Rev Genet 6:893-904 (2005). [Pubmed] Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed] |
| Related annotations: | PaperBLAST |
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