Transcription Factor

Accessions: SOX9_HUMAN (HOCOMOCO 10), P48436 (JASPAR 2024)
Names: SOX9_HUMAN
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 509
Pfam Domains: 22-95 Sox developmental protein N terminal
105-173 HMG (high mobility group) box
106-168 Domain of unknown function (DUF1898)
Sequence:
(in bold interface residues)
1 MNLLDPFMKMTDEQEKGLSGAPSPTMSEDSAGSPCPSGSGSDTENTRPQENTFPKGEPDL 60
61 KKESEEDKFPVCIREAVSQVLKGYDWTLVPMPVRVNGSSKNKPHVKRPMNAFMVWAQAAR 120
121 RKLADQYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRK 180
181 SVKNGQAEAEEATEQTHISPNAIFKALQADSPHSSSGMSEVHSPGEHSGQSQGPPTPPTT 240
241 PKTDVQPGKADLKREGRPLPEGGRQPPIDFRDVDIGELSSDVISNIETFDVNEFDQYLPP 300
301 NGHPGVPATHGQVTYTGSYGISSTAATPASAGHVWMSKQQAPPPPPQQPPQAPPAPQAPP 360
361 QPQAAPPQQPAAPPQQPQAHTLTTLSSEPGQSQRTHIKTEQLSPSHYSEQQQHSPQQIAY 420
421 SPFNLPHYSPSYPPITRSQYDYTDHQNSSSYYSHAAGQGTGLYSTFTYMNPAQRPMYTPI 480
481 ADTSGVPSIPQTHSPQHWEQPVYTQLTRP
Interface Residues: 107, 110, 112, 113, 116, 120, 131, 132, 133, 136, 174, 178
3D-footprint Homologues: 4s2q_D, 1j5n_A, 2lef_A, 4y60_C, 1o4x_B, 3f27_D, 6jrp_D, 1qrv_A, 3u2b_C, 7m5w_A, 2gzk_A, 1hry_A
Binding Motifs: SOX9_HUMAN.H10MO.B|M01522 yCyATTGTTyt
MA0077.1 CyATTGTTy
MA0077.2 CyATTGTT
Binding Sites: MA0077.2.2
MA0077.1.1
MA0077.1.10
MA0077.1.11
MA0077.1.12
MA0077.1.13
MA0077.1.14
MA0077.1.15
MA0077.1.16
MA0077.1.17
MA0077.1.18
MA0077.1.19
MA0077.1.2
MA0077.1.20
MA0077.1.3
MA0077.1.4
MA0077.1.5
MA0077.1.6
MA0077.1.7
MA0077.1.8
MA0077.1.9
MA0077.2.1
MA0077.2.10
MA0077.2.11
MA0077.2.12
MA0077.2.13
MA0077.2.14
MA0077.2.15
MA0077.2.16
MA0077.2.17
MA0077.2.18
MA0077.2.19
MA0077.2.20
MA0077.2.3
MA0077.2.4
MA0077.2.5
MA0077.2.6
MA0077.2.7
MA0077.2.8
MA0077.2.9
Publications: Mertin S., McDowall S. G., Harley V. R. The DNA-binding specificity of SOX9 and other SOX proteins. Nucleic Acids Res. 27:1359-1364 (1999). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.