Transcription Factor
| Accessions: | EGR2_full (HumanTF 1.0) |
| Names: | AT591, E3 SUMO-protein ligase EGR2, Early growth response protein 2, EC 6.3.2.-, EGR-2, EGR2, EGR2_HUMAN, Zinc finger protein Krox-20 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Uniprot: | P11161 |
| Notes: | Ensembl ID: ENSG00000122877; Full protein sequence; TF family: znfC2H2; Clone source: hORFeome |
| Length: | 477 |
| Pfam Domains: | 94-184 Domain of unknown function (DUF3446) 340-364 C2H2-type zinc finger 340-364 Zinc finger, C2H2 type 357-380 Zinc-finger double domain 370-392 C2H2-type zinc finger 370-392 Zinc finger, C2H2 type 384-408 Zinc-finger double domain 398-420 Zinc finger, C2H2 type 398-416 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MMTAKAVDKIPVTLSGFVHQLSDNIYPVEDLAATSVTIFPNAELGGPFDQMNGVAGDGMI 60 61 NIDMTGEKRSLDLPYPSSFAPVSAPRNQTFTYMGKFSIDPQYPGASCYPEGIINIVSAGI 120 121 LQGVTSPASTTASSSVTSASPNPLATGPLGVCTMSQTQPDLDHLYSPPPPPPPYSGCAGD 180 181 LYQDPSAFLSAATTSTSSSLAYPPPPSYPSPKPATDPGLFPMIPDYPGFFPSQCQRDLHG 240 241 TAGPDRKPFPCPLDTLRVPPPLTPLSTIRNFTLGGPSAGVTGPGASGGSEGPRLPGSSSA 300 301 AAAAAAAAAYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRH 360 361 IRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIH 420 421 LRQKERKSSAPSASVPAPSTASCSGGVQPGGTLCSSNSSSLGGGPLAPCSSRTRTP* |
| Interface Residues: | 319, 322, 326, 329, 331, 332, 352, 353, 354, 355, 356, 358, 359, 378, 380, 381, 382, 383, 384, 386, 387, 388, 408, 409, 410, 411, 412, 413, 414, 415, 416, 419 |
| 3D-footprint Homologues: | 8ssq_A, 7w1m_H, 8ssu_A, 5kkq_D, 5ei9_F, 1tf6_A, 2kmk_A, 1tf3_A, 7n5w_A, 6jnm_A, 2jpa_A, 1g2f_F, 7ysf_A, 6ml4_A, 1ubd_C, 6blw_A, 5k5i_A, 6u9q_A, 4x9j_A, 2gli_A, 1f2i_J, 5kl3_A, 2wbs_A, 5v3j_F, 8h9h_G, 6e94_A, 2lt7_A, 6a57_A, 2drp_D, 3uk3_C, 8cuc_F, 7y3l_A, 1llm_D, 5yel_A, 7txc_E, 4m9v_C, 7y3m_I, 8gn3_A, 5yj3_D |
| Binding Motifs: | EGR2_full yhmCGCCCACGCahw |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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