Transcription Factor
| Accessions: | UP00150A (UniPROBE 20160601) |
| Names: | Homeodomain protein IRXB3, Iroquois homeobox protein 6, Iroquois related homeobox 6 (Drosophila), Iroquois-class homeodomain protein IRX-6, Irx6 |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q9ER75 |
| Description: | Iroquois related homeobox 6 (Drosophila) |
| Length: | 96 |
| Pfam Domains: | 19-76 Homeobox domain 34-73 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 LGQYQYDRYGGVELSSAGRRKNATRESTSALKAWLHEHRKNPYPTKGEKIMLAIITKMTL 60 61 TQVSTWFANARRRLKKENKMTWAPKNKGGEERKADS |
| Interface Residues: | 19, 20, 21, 22, 23, 61, 62, 64, 65, 68, 69, 70, 72, 73, 75, 76 |
| 3D-footprint Homologues: | 5zfz_A, 6fqp_B, 1fjl_B, 3d1n_M, 2r5y_A, 1puf_B, 1ig7_A, 1b72_A, 3a01_E, 4cyc_A, 5jlw_D, 3cmy_A, 2lkx_A, 3rkq_B, 2ld5_A, 7xrc_C, 4xrm_B, 1puf_A, 2hdd_A, 1mnm_C, 7psx_B, 4xrs_G, 5zjt_E, 1nk2_P, 5flv_I, 2d5v_B, 1k61_B, 1o4x_A, 1du0_A, 2h1k_B, 1le8_B, 6fqq_E, 2hos_A |
| Binding Motifs: | UP00150A_1 wawrTACATGTAmwwwT |
| Binding Sites: | AAAACATG AAACATGT AACATGTA AACATGTT ACAACATG ACATGTAA ACATGTAC ACATGTAG ACATGTAT ACATGTTA ACATGTTG ATGTACAA ATGTACAC ATGTACAT ATGTTGTA CATGTACA CCTTGTAA TGTACAAA TGTATACA TTGTACAA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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