Transcription Factor
| Accessions: | TCF7_HUMAN (HOCOMOCO 10), P36402 (JASPAR 2024) |
| Names: | T-cell factor 1, T-cell-specific transcription factor 1, TCF-1, TCF-7, TCF7_HUMAN, Transcription factor 7 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P36402 |
| Length: | 384 |
| Pfam Domains: | 1-212 N-terminal CTNNB1 binding 269-336 HMG (high mobility group) box 270-327 Domain of unknown function (DUF1898) |
| Sequence: (in bold interface residues) | 1 MPQLDSGGGGAGGGDDLGAPDELLAFQDEGEEQDDKSRDSAAGPERDLAELKSSLVNESE 60 61 GAAGGAGIPGVPGAGAGARGEAEALGREHAAQRLFPDKLPEPLEDGLKAPECTSGMYKET 120 121 VYSAFNLLMHYPPPSGAGQHPQPQPPLHKANQPPHGVPQLSLYEHFNSPHPTPAPADISQ 180 181 KQVHRPLQTPDLSGFYSLTSGSMGQLPHTVSWFTHPSLMLGSGVPGHPAAIPHPAIVPPS 240 241 GKQELQPFDRNLKTQAESKAEKEAKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAIN 300 301 QILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREKHQESTTET 360 361 NWPRELKDGNGQESLSMSSSSSPA |
| Interface Residues: | 271, 274, 276, 277, 280, 284, 295, 296, 297, 300, 338, 340, 342, 345 |
| 3D-footprint Homologues: | 7m5w_A, 2gzk_A, 4s2q_D, 2lef_A, 4y60_C, 1j5n_A, 3f27_D, 6jrp_D, 1o4x_B, 3u2b_C, 1hry_A |
| Binding Motifs: | TCF7_HUMAN.H10MO.C|M01560 aswwCAAAGsry MA0769.2 kyCTTTGAwst MA0769.3 CTTTGAw |
| Binding Sites: | MA0769.3.16 / MA0769.3.17 / MA0769.3.18 / MA0769.3.19 MA0769.3.11 / MA0769.3.13 / MA0769.3.20 / MA0769.3.3 / MA0769.3.4 / MA0769.3.5 / MA0769.3.8 MA0769.2.1 MA0769.2.10 / MA0769.2.11 MA0769.2.11 / MA0769.2.12 MA0769.2.12 / MA0769.2.13 MA0769.2.13 MA0769.2.14 MA0769.2.15 MA0769.2.16 MA0769.2.17 MA0769.2.18 MA0769.2.19 MA0769.2.1 / MA0769.2.2 MA0769.2.20 MA0769.2.3 MA0769.2.4 MA0769.2.5 MA0769.2.6 MA0769.2.7 MA0769.2.8 MA0769.2.9 MA0769.2.10 MA0769.2.2 MA0769.2.6 MA0769.2.7 MA0769.3.9 MA0769.3.1 / MA0769.3.14 / MA0769.3.15 / MA0769.3.7 MA0769.3.10 MA0769.3.12 MA0769.3.2 MA0769.3.6 |
| Publications: | Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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