Transcription Factor
| Accessions: | 5i50_A (3D-footprint 20231221) |
| Names: | bHLHe39, Class E basic helix-loop-helix protein 39, Myc proto-oncogene protein, MYC_HUMAN, Proto-oncogene c-Myc, Transcription factor p64 |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P01106 |
| Length: | 92 |
| Pfam Domains: | 8-60 Helix-loop-helix DNA-binding domain 61-92 Myc leucine zipper domain |
| Sequence: (in bold interface residues) | 1 MATEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQ 60 61 AETQKLISEIDLLRKQNEQLKHKLEQLRNSCA |
| Interface Residues: | 9, 11, 12, 13, 15, 16, 17, 19, 20, 21, 25, 45, 85, 86, 87, 88, 89 |
| 3D-footprint Homologues: | 7z5k_B, 1a0a_B, 1an4_A, 1am9_A, 7rcu_E, 5gnj_I, 6g1l_A, 7ssa_L, 5i50_B, 7d8t_A, 4zpk_A, 7xi3_A, 5nj8_D, 7f2f_B, 5eyo_A, 5v0l_A, 7xq5_A, 8eb5_A, 8edg_C |
| Binding Motifs: | 5i50_AB CCACGTGAA |
| Publications: | Jung LA, Gebhardt A, Koelmel W, Ade CP, Walz S, Kuper J, von Eyss B, Letschert S, Redel C, d'Artista L, Biankin A, Zender L, Sauer M, Wolf E, Evan G, Kisker C, Eilers M. OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors. Oncogene : (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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