Transcription Factor

						

			
Accessions: PAX2_DBD (HumanTF 1.0), PAX2 (HT-SELEX2 May2017)

			
Names: PAX2, PAX2_HUMAN, ENSG00000075891
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, HT-SELEX2 May2017 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Uniprot: Q02962
Notes: Ensembl ID: ENSG00000075891; DNA-binding domain sequence; TF family: PAX; Clone source: Gene synthesis, TF family: PAX experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: PAX experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4
Length: 293
Pfam Domains:    15-139 'Paired box' domain
Sequence: 
(in bold interface residues)		   1 DMHCKADPFSAMHPGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVS   60
  61 HGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAE  120
 121 GICDNDTVPSVSSINRIIRTKVQQPFHPTPDGAGTGVTAPGHTIVPSTASPPVSSASNDP  180
 181 VGSYSINGILGIPRSNGEKRKRDEVEVYTDPAHIRGGGGLHLVWTLRDVSEGSVPNGDSQ  240
 241 SGVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIKSEQGNEYSLP
Interface Residues: 28, 60, 61, 63, 65, 66, 82, 85, 88, 130, 131, 132, 133, 135, 136, 139
3D-footprint Homologues: 6pax_A, 1k78_A, 1pdn_C
Binding Motifs: PAX2_DBD sGTCACGCwTsRsTGmky
PAX2_2 ccGtCACGCwysrsyrcsym
PAX2_methyl_1 ysGTCACGCwTsAsyGmwya
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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