Transcription Factor

Accessions: UP00222A (UniPROBE 20160601)
Names: AI385728, AI987804, Hepatocyte nuclear factor 1-beta, hepatocyte nuclear factor-1 beta, Hnf-1b, HNF-1beta, Hnf1b, Hnf1beta, Homeoprotein LFB3, Tcf-2, Tcf2, transcription factor 2, Variant hepatic nuclear factor 1, vHNF1
Organisms: Mus musculus
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: P27889
Description: transcription factor 2: TCF2 gene, VIRTUAL TRANSCRIPT, partial sequence, genomic survey sequence
Length: 114
Pfam Domains: 17-90 Homeobox domain
Sequence:
(in bold interface residues)
1 PGQSEDTCSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAECLQ 60
61 RGVSPSKAHGLGSNLVTEVRVYNWFANRRKEEAFRQKLAMDACSSNQTHNLNPL
Interface Residues: 17, 20, 80, 81, 82, 83, 86, 87, 90
3D-footprint Homologues: 5zfz_A, 1fjl_B, 1ic8_B, 4j19_B, 2h8r_B, 1le8_A, 7q3o_C, 3cmy_A, 5zjt_E, 3rkq_B
Binding Motifs: UP00222A_1 dkykGTTAACTAryybt
Binding Sites: AACTAACC
ACTAACTA
ACTAGTTA
AGGTTAAC
AGTTAACC
AGTTAACT
ATAACTAG
ATTAACTA
CGGTTAAC
CTAACTAG
CTAGTTAA
CTGGTTAA
CTTAACTA
GGTTAACC
GTAGTTAA
GTTAACCA
GTTAGTTA
TAACTAGA
TTAACCAA
TTAACTAA
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.