Transcription Factor
| Accessions: | P18848 (JASPAR 2024) |
| Names: | Activating transcription factor 4, ATF4_HUMAN, cAMP-dependent transcription factor ATF-4, cAMP-responsive element-binding protein 2, CREB-2, Cyclic AMP-dependent transcription factor ATF-4, Cyclic AMP-responsive element-binding protein 2, DNA-binding protein TAXREB67, Tax-responsive enhancer element-binding protein 67, TaxREB67 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P18848 |
| Length: | 351 |
| Pfam Domains: | 276-337 bZIP transcription factor 279-330 Basic region leucine zipper |
| Sequence: (in bold interface residues) | 1 MTEMSFLSSEVLVGDLMSPFDQSGLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSE 60 61 WLAVDGLVSPSNNSKEDAFSGTDWMLEKMDLKEFDLDALLGIDDLETMPDDLLTTLDDTC 120 121 DLFAPLVQETNKQPPQTVNPIGHLPESLTKPDQVAPFTFLQPLPLSPGVLSSTPDHSFSL 180 181 ELGSEVDITEGDRKPDYTAYVAMIPQCIKEEDTPSDNDSGICMSPESYLGSPQHSPSTRG 240 241 SPNRSLPSPGVLCGSARPKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQKKR 300 301 AEQEALTGECKELEKKNEALKERADSLAKEIQYLKDLIEEVRKARGKKRVP |
| Interface Residues: | 284, 288, 291, 292, 295, 296 |
| 3D-footprint Homologues: | 2wt7_A, 2wt7_B |
| Binding Motifs: | MA0833.1 ggaTGAyGCAAYm MA0833.2 rraTGATGCAATmw MA0833.3 aTGATGCAAT |
| Binding Sites: | MA0833.2.1 MA0833.2.14 / MA0833.2.16 MA0833.2.10 / MA0833.2.8 MA0833.2.11 MA0833.2.10 / MA0833.2.12 MA0833.2.13 MA0833.2.11 / MA0833.2.14 MA0833.2.13 / MA0833.2.15 MA0833.2.17 MA0833.2.15 / MA0833.2.18 MA0833.2.16 / MA0833.2.19 MA0833.2.2 MA0833.2.17 / MA0833.2.20 MA0833.2.3 MA0833.2.3 / MA0833.2.4 MA0833.2.4 / MA0833.2.5 MA0833.2.5 / MA0833.2.6 MA0833.2.6 / MA0833.2.7 MA0833.2.8 MA0833.2.7 / MA0833.2.9 MA0833.2.12 MA0833.2.18 MA0833.2.19 MA0833.2.20 MA0833.2.9 MA0833.3.1 MA0833.3.10 / MA0833.3.19 MA0833.3.11 / MA0833.3.2 MA0833.3.12 MA0833.3.13 MA0833.3.14 MA0833.3.15 MA0833.3.16 / MA0833.3.17 MA0833.3.18 MA0833.3.20 MA0833.3.3 MA0833.3.4 / MA0833.3.5 / MA0833.3.7 MA0833.3.6 MA0833.3.8 MA0833.3.9 |
| Publications: | Hai T., Liu F., Coukos W. J., Green M. R. Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. Genes Dev. 3:2083-2090 (1989). [Pubmed] Lee SH, Min KW, Zhang X, Baek SJ. 3,3'-diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells. J Nutr Biochem 24:664-71 (2013). [Pubmed] |
| Related annotations: | PaperBLAST |
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