Transcription Factor

						

			
Accessions: 1zrf_A (3D-footprint 20231221), 3n4m_A (3D-footprint 20231221), 5ciz_A (3D-footprint 20231221)

			
Names: cAMP receptor protein, cAMP regulatory protein, cAMP-activated global transcriptional regulator CRP, CAP, Catabolite activator protein, Catabolite gene activator, CRP_ECOLI
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P0ACJ8
Length: 203
Pfam Domains:    16-104 Cyclic nucleotide-binding domain
  135-199 Crp-like helix-turn-helix domain
  159-190 Bacterial regulatory proteins, crp family
Sequence: 
(in bold interface residues)		   1 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQ   60
  61 GDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQV  120
 121 TSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRI  180
 181 LKMLEDQNLISAHGKTIVVYGTR
Interface Residues: 20, 74, 159, 164, 173, 174, 175, 176, 178, 179
3D-footprint Homologues: 3iyd_H, 4a12_B, 2xro_E, 3q5f_A, 7pza_B, 3e6c_C, 4i2o_B, 3mzh_A, 5i2d_R
Binding Motifs: 1zrf_A CGnnnnnTGCG
3n4m_ABC TwnnnnnnnnnnTGtGA
5ciz_A TCacA
5ciz_AB TCacA
Binding Sites: 3n4m_E
3n4m_D
1zrf_W
1zrf_X
5ciz_D
5ciz_E
			
Publications: Napoli A.A, Lawson C.L, Ebright R.H, Berman H.M. Indirect readout of DNA sequence at the primary-kink site in the CAP-DNA complex: recognition of pyrimidine-purine and purine-purine steps. Journal of molecular biology 357:173-83 (2006). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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