Transcription Factor
Accessions: | 1zrf_A (3D-footprint 20231221), 3n4m_A (3D-footprint 20231221), 5ciz_A (3D-footprint 20231221) |
Names: | cAMP receptor protein, cAMP regulatory protein, cAMP-activated global transcriptional regulator CRP, CAP, Catabolite activator protein, Catabolite gene activator, CRP_ECOLI |
Organisms: | Escherichia coli, strain K12 |
Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
Uniprot: | P0ACJ8 |
Length: | 203 |
Pfam Domains: | 16-104 Cyclic nucleotide-binding domain 135-199 Crp-like helix-turn-helix domain 159-190 Bacterial regulatory proteins, crp family |
Sequence: (in bold interface residues) | 1 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQ 60 61 GDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQV 120 121 TSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRI 180 181 LKMLEDQNLISAHGKTIVVYGTR |
Interface Residues: | 20, 74, 159, 164, 173, 174, 175, 176, 178, 179 |
3D-footprint Homologues: | 3iyd_H, 4a12_B, 2xro_E, 4i2o_B, 3mzh_A, 5i2d_R, 3q5f_A, 7pza_B, 3e6c_C |
Binding Motifs: | 1zrf_A CGnnnnnTGCG 3n4m_ABC TwnnnnnnnnnnTGtGA 5ciz_A TCacA 5ciz_AB TCacA |
Binding Sites: | 3n4m_E 3n4m_D 1zrf_W 1zrf_X 5ciz_D 5ciz_E |
Publications: | Napoli A.A, Lawson C.L, Ebright R.H, Berman H.M. Indirect readout of DNA sequence at the primary-kink site in the CAP-DNA complex: recognition of pyrimidine-purine and purine-purine steps. Journal of molecular biology 357:173-83 (2006). [Pubmed] |
Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.