Transcription Factor
| Accessions: | UP00282A (UniPROBE 20160601) |
| Names: | Lys14, Lysine biosynthesis regulatory protein LYS14, YD9673.04C, YDR034C |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P40971 |
| Description: | Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer |
| Length: | 140 |
| Pfam Domains: | 52-88 Fungal Zn(2)-Cys(6) binuclear cluster domain |
| Sequence: (in bold interface residues) | 1 PTTSEQDQNADHPTISQADDNGHSSLTPNPAVTSTVTDKKGNTVKRKYSRNGCSECKRRR 60 61 MKCDETKPTCWQCARLNRQCVYVLNPKNKKRRTSNAQRVKEFRKHSTSLDNDHNNARKRQ 120 121 HSSCKAEKKKKVRQNLSEDT |
| Interface Residues: | 51, 59, 60, 61, 74, 88 |
| 3D-footprint Homologues: | 8hbm_B, 2er8_C, 6o19_A, 1hwt_C, 1pyi_A, 1zme_D, 1d66_B, 3coq_A, 7uik_T, 6gys_C, 6jrp_D |
| Binding Motifs: | UP00282A_1 ywcymrAAATTCCGkkckhy |
| Binding Sites: | AAATTCCG AATTCCGA AATTCCGC AATTCCGG AATTCCGT AATTTCCG ACGGAATA ATATTCCG ATTCCGGA ATTCCGGG ATTCCGTA ATTCCGTG CAATTCCG CGGAATAA CGGAATTA CGGAATTC GAAATTCC GGAATTCC GGAATTTA AAGGAATT |
| Publications: | *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed] |
| Related annotations: | PaperBLAST |
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