Transcription Factor

Accessions: 2r5y_B (3D-footprint 20231221), 2r5z_B (3D-footprint 20231221)
Names: Dpbx, EXD_DROME, Homeobox protein extradenticle
Organisms: Drosophila melanogaster
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P40427
Length: 59
Pfam Domains: 1-57 Homeobox domain
16-54 Homeobox KN domain
Sequence:
(in bold interface residues)
1 RRNFSKQASEILNEYFYSHLSNPYPSEEAKEELARKCGITVSQVSNWFGNKRIRYKKNI
Interface Residues: 1, 2, 4, 42, 43, 45, 46, 49, 50, 53, 54, 57
3D-footprint Homologues: 1fjl_B, 4j19_B, 1au7_A, 5zjt_E, 3cmy_A, 1b72_A, 1puf_B, 3d1n_M, 2lkx_A, 5jlw_D, 2ld5_A, 7q3o_C, 1ic8_B, 1le8_A, 1ig7_A, 1le8_B, 6m3d_C, 1du0_A, 4cyc_A, 2r5y_A, 1zq3_P, 1jgg_B, 6es3_K, 4xrs_G, 3l1p_A, 1mnm_C, 7psx_B, 5zfz_A, 3a01_E, 2d5v_B, 1k61_B, 6fqp_B, 5flv_I, 3lnq_A, 1puf_A, 4qtr_D, 2h1k_B, 6fqq_E, 5hod_A, 3rkq_B, 8g87_X, 6a8r_A, 4xrm_B, 2hdd_A, 2hos_A
Binding Motifs: 2r5y_AB TGATTTAwgG
2r5z_AB AGATTAATcGG
2r5z_B aGAt
Binding Sites: 2r5y_C
2r5y_D
2r5z_C
2r5z_D
Publications: Joshi R, Passner J.M, Rohs R, Jain R, Sosinsky A, Crickmore M.A, Jacob V, Aggarwal A.K, Honig B, Mann R.S. Functional specificity of a Hox protein mediated by the recognition of minor groove structure. Cell 131:530-43 (2007). [Pubmed]
Related annotations: PaperBLAST

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