Transcription Factor

						

			
Accessions: 7khi_F (3D-footprint 20231221)

			
Names: RNA polymerase sigma factor RpoD, RPOD_ECOLI, Sigma-70
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P00579
Length: 556
Pfam Domains:      1-75 Sigma-70 factor, region 1.1
   90-121 Sigma-70 factor, region 1.2
  132-163 Sigma-70, non-essential region
  162-292 Sigma-70, non-essential region
  323-393 Sigma-70 region 2 
  402-478 Sigma-70 region 3
  491-544 Sigma-70, region 4
Sequence: 
(in bold interface residues)		   1 QSQLKLLVTRGKEQGYLTYAEVNDHLPEDIVDSDQIEDIIQMINDMGIQVMEEAPDADDL   60
  61 MLAENTADEDAAEAAAQVLSSVESEIGRTTDPVRMYMREMGTVELLTREGEIDIAKRIED  120
 121 GINQVQCSVAEYPEAITYLLEQYDRVEAEEARLSDLITGFVDDPELAREKFAELRAQYVV  180
 181 TRDTIKATAQEEILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKLCVEQCK  240
 241 MPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRALQKLQQIEEETGLTIE  300
 301 QVKDINRRMSIGEAKARRAKKEMVEANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAV  360
 361 DKFEYRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIETINKLNRISRQMLQEMGR  420
 421 EPTPEELAERMLMPEDKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSAT  480
 481 TESLRAATHDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQIEAKALR  540
 541 KLRHPSRSEVLRSFLD
Interface Residues: 196, 206, 208, 209, 211, 212, 517, 518, 527, 528, 529, 530, 532, 533
3D-footprint Homologues: 3h0d_A, 3n97_A, 6ido_B, 8cyf_B
Binding Motifs: 7khi_F Agnnwnnnnnnnnnnnnnnacaag
Binding Sites: 7khi_X
7khi_Y
			
Publications: Shin Y, Qayyum MZ, Pupov D, Esyunina D, Kulbachinskiy A, Murakami KS. Structural basis of ribosomal RNA transcription regulation. Nat Commun 12:528 (2021). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
Disclaimer and license


These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.